Introduction Functional imaging of narcolepsy type 1 (NT1) has shown disparate results, with evid... more Introduction Functional imaging of narcolepsy type 1 (NT1) has shown disparate results, with evidence for both regional hyper- and hypo-metabolism. A FDG-PET study of idiopathic hypersomnia (IH) demonstrated regional hypermetabolism within the salience network. Methods Patients with NT1 (n=14) or IH (n=16) were recruited, with age-matched, non-sleepy controls (HC, n=8). Patients discontinued treatment for ≥5 half-lives. Participants underwent injection of 18F-fludeoxyglucose (FDG) in a dimly-lit room and were asked to remain awake, seated quietly. Simultaneous 6-channel EEG, EOG, and EMG were collected. Participants were alerted by a loud noise if sleep onset was observed. Thirty minutes after injection, patients underwent 36-minute PET scan. Images were spatially normalized to MPRAGE images and analyzed for group differences using SPM8. Results Groups were similar in age (NT1: 30.0 (+/-SD 8.3), IH: 36.3 (+/-12.4), HC: 33.2 (+/-16.2), p=0.29) and gender (%women, NT1: 71%, IH: 87.5%,...
A dearth of women leaders in the field of radiology and affiliated industries persists despite a ... more A dearth of women leaders in the field of radiology and affiliated industries persists despite a recognition of the importance, value, and impact that would derive from its rectification. A targeted educational collaboration, described herein, was established between academia and industry to address this deficit and to facilitate the placement of highly qualified women into leadership positions. The actionable platform offered has the potential to narrow the gap for underrepresented groups in professional leadership positions.
La mejora en los procedimientos de las tecnicas neurorradiologicas in vivo para la investigacion ... more La mejora en los procedimientos de las tecnicas neurorradiologicas in vivo para la investigacion de la estructura y el funcionamiento del cerebro de los individuos mayores ha permitido profundizar en el conocimiento de los fundamentos biologicos del envejecimiento normal y de las alteraciones psiquiatricas y neurologicas caracteristicas de la edad avanzada. Mientras que los estudios posmortem se centran en las ultimas etapas de una enfermedad, las tecnicas de imagen funcionales y estructurales nos han permitido caracterizar los cambios que tienen lugar en el cerebro durante las primeras fases de la enfermedad de Alzheimer (EA). El desarrollo de tecnicas terapeuticas mas eficaces, que pueden enlentecer y, potencialmente, invertir el avance de la enfermedad, ha hecho que las tecnicas basadas en la resonancia magnetica sean una herramienta fundamental para detectar el estado preclinico de la EA. Por tanto, el uso de procedimientos no invasivos para identificar el deterioro cognitivo leve (DCL), considerado un estadio transitorio entre el envejecimiento normal y la EA, es un objetivo de una importancia fundamental para la salud publica mundial. En este articulo haremos una revision de las nuevas estrategias de neuroimagen que pueden emplearse para diagnosticar el DCL.
The structural organization of the dura and leptomeninges is reflected in its magnetic resonance ... more The structural organization of the dura and leptomeninges is reflected in its magnetic resonance (MR) imaging appearance in normal and disease states. Two distinct enhancement patterns are characterized: dura-arachnoid enhancement and pia-subarachnoid space enhancement. The dura-arachnoid pattern consists of curvilinear enhancement overlying the brain and immediately deep to the inner table of the calvaria, as well as along the falx and tentorium. Pial enhancement closely follows the brain surface into sulci and outlines the basal cisterns. Recognition of these enhancement patterns and other MR imaging characteristics may enhance the role of MR imaging in the detection, diagnosis, and follow-up of neoplastic and nonneoplastic disorders affecting the meninges. The focus of this article (Part I) is the MR appearance of the normal meninges and nonneoplastic causes of meningeal disease. Part II of this series will discuss neoplastic conditions affecting the coverings of the brain and spinal cord with an emphasis on pathways of disease spread.
LEARNING OBJECTIVES 1) Identify the different grant mechanisms available within the NIH and the r... more LEARNING OBJECTIVES 1) Identify the different grant mechanisms available within the NIH and the requirements for submitting to a particular mechanism. 2) List the criteria used in the evaluation of NIH grants and what happens prior to and during a study section review meeting. 3) Articulate the benefits of being a reviewer for the NIH and the different ways that one can be a reviewer. 4) Observe a mock study section presented by the NIH with experienced reviewers evaluating at least two grant mechanisms. ABSTRACT This workshop designed to provide information to radiologists and imaging scientists interested in serving as expert peer reviewers on NIH and other grant study sections. Although a significant amount of information is available on how the review process works, many investigators (new and experienced) have questions that are best answered in person by those who have first-hand experience. Attendees will be provided with a clearer understanding of the review process, enablin...
LEARNING OBJECTIVES 1) How to produce patient education videos. 2) How to deploy them in a patien... more LEARNING OBJECTIVES 1) How to produce patient education videos. 2) How to deploy them in a patient care setting. 3) How to measure the impact on patient satisfaction.
Journal of the American Optometric Association, 1997
Monozygotic (MZ) or "identical" twins arise from a single fertilized egg, which divides... more Monozygotic (MZ) or "identical" twins arise from a single fertilized egg, which divides into two embryos at an early stage of development. As a result, MZ twins have identical genomes and are always of the same sex. A case of optic nerve hypoplasia and anisometropia, in association with mirror-image presentation in a set of 12-year-old identical twins, is reported. The monozygotic twinning event responsible for identical twins--as well as the rare phenomenon of mirror imaging--is described. The combined occurrence of anisometropia and optic nerve hypoplasia in mirror-image presentation in a set of monozygotic twins provides a unique opportunity to study the genetic versus environmental influences on the development of optic nerve hypoplasia. Although the cause of optic nerve hypoplasia remains unclear, its associated mirror-image presentation in this case suggests a possible genetic predisposition.
Physical Medicine and Rehabilitation Clinics of North America, 2003
Laboratory studies have established the potential for neuronal transplantation to be of benefit t... more Laboratory studies have established the potential for neuronal transplantation to be of benefit to patients. Experimental studies in normal animals indicate that brain implantation of neurons seems safe. Implanted neurons integrated with the host brain, sent out axonal processes to communicate with other nerve cells, released transmitters (the chemical messengers of nerve cell communication), and demonstrated typical neuronal proteins. This article discusses phase I and II trials of neuronal transplantation in humans with small strokes in critical brain locations such as the basal ganglia region. More work is needed to confirm safety and to identify optimal measures of efficacy in this setting.
Introduction Functional imaging of narcolepsy type 1 (NT1) has shown disparate results, with evid... more Introduction Functional imaging of narcolepsy type 1 (NT1) has shown disparate results, with evidence for both regional hyper- and hypo-metabolism. A FDG-PET study of idiopathic hypersomnia (IH) demonstrated regional hypermetabolism within the salience network. Methods Patients with NT1 (n=14) or IH (n=16) were recruited, with age-matched, non-sleepy controls (HC, n=8). Patients discontinued treatment for ≥5 half-lives. Participants underwent injection of 18F-fludeoxyglucose (FDG) in a dimly-lit room and were asked to remain awake, seated quietly. Simultaneous 6-channel EEG, EOG, and EMG were collected. Participants were alerted by a loud noise if sleep onset was observed. Thirty minutes after injection, patients underwent 36-minute PET scan. Images were spatially normalized to MPRAGE images and analyzed for group differences using SPM8. Results Groups were similar in age (NT1: 30.0 (+/-SD 8.3), IH: 36.3 (+/-12.4), HC: 33.2 (+/-16.2), p=0.29) and gender (%women, NT1: 71%, IH: 87.5%,...
A dearth of women leaders in the field of radiology and affiliated industries persists despite a ... more A dearth of women leaders in the field of radiology and affiliated industries persists despite a recognition of the importance, value, and impact that would derive from its rectification. A targeted educational collaboration, described herein, was established between academia and industry to address this deficit and to facilitate the placement of highly qualified women into leadership positions. The actionable platform offered has the potential to narrow the gap for underrepresented groups in professional leadership positions.
La mejora en los procedimientos de las tecnicas neurorradiologicas in vivo para la investigacion ... more La mejora en los procedimientos de las tecnicas neurorradiologicas in vivo para la investigacion de la estructura y el funcionamiento del cerebro de los individuos mayores ha permitido profundizar en el conocimiento de los fundamentos biologicos del envejecimiento normal y de las alteraciones psiquiatricas y neurologicas caracteristicas de la edad avanzada. Mientras que los estudios posmortem se centran en las ultimas etapas de una enfermedad, las tecnicas de imagen funcionales y estructurales nos han permitido caracterizar los cambios que tienen lugar en el cerebro durante las primeras fases de la enfermedad de Alzheimer (EA). El desarrollo de tecnicas terapeuticas mas eficaces, que pueden enlentecer y, potencialmente, invertir el avance de la enfermedad, ha hecho que las tecnicas basadas en la resonancia magnetica sean una herramienta fundamental para detectar el estado preclinico de la EA. Por tanto, el uso de procedimientos no invasivos para identificar el deterioro cognitivo leve (DCL), considerado un estadio transitorio entre el envejecimiento normal y la EA, es un objetivo de una importancia fundamental para la salud publica mundial. En este articulo haremos una revision de las nuevas estrategias de neuroimagen que pueden emplearse para diagnosticar el DCL.
The structural organization of the dura and leptomeninges is reflected in its magnetic resonance ... more The structural organization of the dura and leptomeninges is reflected in its magnetic resonance (MR) imaging appearance in normal and disease states. Two distinct enhancement patterns are characterized: dura-arachnoid enhancement and pia-subarachnoid space enhancement. The dura-arachnoid pattern consists of curvilinear enhancement overlying the brain and immediately deep to the inner table of the calvaria, as well as along the falx and tentorium. Pial enhancement closely follows the brain surface into sulci and outlines the basal cisterns. Recognition of these enhancement patterns and other MR imaging characteristics may enhance the role of MR imaging in the detection, diagnosis, and follow-up of neoplastic and nonneoplastic disorders affecting the meninges. The focus of this article (Part I) is the MR appearance of the normal meninges and nonneoplastic causes of meningeal disease. Part II of this series will discuss neoplastic conditions affecting the coverings of the brain and spinal cord with an emphasis on pathways of disease spread.
LEARNING OBJECTIVES 1) Identify the different grant mechanisms available within the NIH and the r... more LEARNING OBJECTIVES 1) Identify the different grant mechanisms available within the NIH and the requirements for submitting to a particular mechanism. 2) List the criteria used in the evaluation of NIH grants and what happens prior to and during a study section review meeting. 3) Articulate the benefits of being a reviewer for the NIH and the different ways that one can be a reviewer. 4) Observe a mock study section presented by the NIH with experienced reviewers evaluating at least two grant mechanisms. ABSTRACT This workshop designed to provide information to radiologists and imaging scientists interested in serving as expert peer reviewers on NIH and other grant study sections. Although a significant amount of information is available on how the review process works, many investigators (new and experienced) have questions that are best answered in person by those who have first-hand experience. Attendees will be provided with a clearer understanding of the review process, enablin...
LEARNING OBJECTIVES 1) How to produce patient education videos. 2) How to deploy them in a patien... more LEARNING OBJECTIVES 1) How to produce patient education videos. 2) How to deploy them in a patient care setting. 3) How to measure the impact on patient satisfaction.
Journal of the American Optometric Association, 1997
Monozygotic (MZ) or "identical" twins arise from a single fertilized egg, which divides... more Monozygotic (MZ) or "identical" twins arise from a single fertilized egg, which divides into two embryos at an early stage of development. As a result, MZ twins have identical genomes and are always of the same sex. A case of optic nerve hypoplasia and anisometropia, in association with mirror-image presentation in a set of 12-year-old identical twins, is reported. The monozygotic twinning event responsible for identical twins--as well as the rare phenomenon of mirror imaging--is described. The combined occurrence of anisometropia and optic nerve hypoplasia in mirror-image presentation in a set of monozygotic twins provides a unique opportunity to study the genetic versus environmental influences on the development of optic nerve hypoplasia. Although the cause of optic nerve hypoplasia remains unclear, its associated mirror-image presentation in this case suggests a possible genetic predisposition.
Physical Medicine and Rehabilitation Clinics of North America, 2003
Laboratory studies have established the potential for neuronal transplantation to be of benefit t... more Laboratory studies have established the potential for neuronal transplantation to be of benefit to patients. Experimental studies in normal animals indicate that brain implantation of neurons seems safe. Implanted neurons integrated with the host brain, sent out axonal processes to communicate with other nerve cells, released transmitters (the chemical messengers of nerve cell communication), and demonstrated typical neuronal proteins. This article discusses phase I and II trials of neuronal transplantation in humans with small strokes in critical brain locations such as the basal ganglia region. More work is needed to confirm safety and to identify optimal measures of efficacy in this setting.
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