Synthesis and Biological Evaluation of Ebselen and Its Acyclic Derivatives

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Tsu-Chung Chang, Mei-Lan Huang, Wen-Lin Hsu, Jing-Min Hwang, Ling-Yih Hsu

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Keywords: ebselen derivative, selenoorganic compound, antioxidant, peroxynitrite, glutathione peroxidase

JOURNAL FREE ACCESS

2003 Volume 51 Issue 12 Pages 1413-1416

DOI https://doi.org/10.1248/cpb.51.1413

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Abstract

Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen.

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