doiSerbia

Cytogenetic and molecular genetic characterization of 28 Serbian and Montenegrian neuroblastoma patients

Đurišić Marina (Institut za zdravstvenu zaštitu majke i deteta 'Dr. Vukan Čupić', Beograd)
Guć-Šćekić Marija P. (Institut za zdravstvenu zaštitu majke i deteta 'Dr. Vukan Čupić', Beograd)
Đokić Dragana (Institut za zdravstvenu zaštitu majke i deteta 'Dr. Vukan Čupić', Beograd)
Vujić Dragana S. (Medicinski fakultet, Univerzitet u Beogradu)
Milović S. (Medicinski fakultet, Univerzitet u Beogradu)
Đurišić S. (Biološki fakultet, Univerzitet u Beogradu)
Radivojević Danijela (Biološki fakultet, Univerzitet u Beogradu)
Lalić Tanja (Biološki fakultet, Univerzitet u Beogradu)
Đurić Milena L. (Medicinski fakultet, Univerzitet u Beogradu)

Neuroblastoma (NB) is a malignant childhood solid tumor of neuroectodermal cells. Clinical behavior of neuroblastomas is largely diverse - from spontaneous regression to rapid progression with a fatal outcome. From the analysis of bone marrow and tumors of NB patients at the cytogenetic molecular cytogenetic and molecular level non-random genetic changes have been identified, including ploidy changes, amplification of the N-myc oncogene and deletions of chromosome 1p. In this paper we present the cytogenetic, fluorescence in situ hybridization and molecular findings in 28 Serbian and Montenegrian NB patients. Reliable detection of these features should be regarded as mandatory for all new cases.