[go: up one dir, main page]

Skip to main content

ApiNATOMY: Towards Multiscale Views of Human Anatomy

  • Conference paper
Advances in Intelligent Data Analysis XIII (IDA 2014)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 8819))

Included in the following conference series:

Abstract

Physiology experts deal with complex biophysical relationships, across multiple spatial and temporal scales. Automating the discovery of such relationships, in terms of physiological meaning, is a key goal to the physiology community. ApiNATOMY is an effort to provide an interface between the physiology expert’s knowledge and all ranges of data relevant to physiology. It does this through an intuitive graphical interface for managing semantic metadata and ontologies relevant to physiology. In this paper, we present a web-based ApiNATOMY environment, allowing physiology experts to navigate through circuitboard visualizations of body components, and their cardiovascular and neural connections, across different scales. Overlaid on these schematics are graphical renderings of organs, neurons and gene products, as well as mathematical models of processes semantically annotated with this knowledge.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. de Bono, B., Hoehndorf, R., Wimalaratne, S., Gkoutos, G., Grenon, P.: The RICORDO approach to semantic interoperability for biomedical data and models: strategy, standards and solutions. BMC Research Notes 4, 313 (2011)

    Article  Google Scholar 

  2. Katifori, A., Halatsis, C., Lepouras, G., Vassilakis, C., Giannopoulou, E.: Ontology visualization methods - a survey. ACM Comput. Surv. 39(4) (2007)

    Google Scholar 

  3. Blake, J.A., et al.: Gene ontology annotations and resources. Nucleic Acids Res. 535, D530–D535 (2013)

    Google Scholar 

  4. Hastings, J., de Matos, P., Dekker, A., Ennis, M., Harsha, B., Kale, N., Muthukrishnan, V., Owen, G., Turner, S., Williams, M., Steinbeck, C.: The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013. Nucleic Acids Res. 41(D1), D456–D463 (2013)

    Google Scholar 

  5. Bard, J., Rhee, S.Y., Ashburner, M.: An ontology for cell types. Genome Biol. 6(2), R21 (2005)

    Google Scholar 

  6. Rosse, C., Mejino Jr., J.L.V.: A reference ontology for biomedical informatics: the foundational model of anatomy. J. Biomed. Inform. 36(6), 478–500 (2003)

    Article  Google Scholar 

  7. EBI: Arrayexpress home, EBI (2012), http://www.ebi.ac.uk/arrayexpress/

  8. Harnisch, L., Matthews, I., Chard, J., Karlsson, M.O.: Drug and disease model resources: a consortium to create standards and tools to enhance model-based drug development. CPT Pharmacomet. Syst. Pharmacol. 2, e34 (2013)

    Google Scholar 

  9. de Bono, B., Grenon, P., Sammut, S.: ApiNATOMY: A novel toolkit for visualizing multiscale anatomy schematics with phenotype-related information. Hum. Mutat. 33(5), 837–848 (2012)

    Article  Google Scholar 

  10. Kokash, N., de Bono, B.J.K.: Template-based treemaps to preserve spatial constraints. In: Proc. IVAPP 2014 (2014)

    Google Scholar 

  11. de Bono, B.: Achieving semantic interoperability between physiology models and clinical data. In: Proc. of IEEE Int. Conf. on e-Science Workshops, pp. 135–142 (2011)

    Google Scholar 

  12. Gardner, D., et al.: The neuroscience information framework: A data and knowledge environment for neuroscience. Neuroinformatics 6(3), 149–160 (2008)

    Article  Google Scholar 

  13. Mitsuhashi, N., Fujieda, K., Tamura, T., Kawamoto, S., Takagi, T., Okubo, K.: Bodyparts3d: 3d structure database for anatomical concepts. Nucleic Acids Res. 37, D782–D785 (2009)

    Google Scholar 

  14. Ascoli, G.A.: Mobilizing the base of neuroscience data: the case of neuronal morphologies. Nat. Rev. Neurosci. 7(4), 318–324 (2006)

    Article  Google Scholar 

  15. Johnson, B., Shneiderman, B.: Tree-maps: a space-filling approach to the visualization of hierarchical information structures. In: Proc. of the 2nd Conference on Visualization 1991, pp. 284–291. IEEE (1991)

    Google Scholar 

  16. Blanch, R., Lecolinet, E.: Browsing zoomable treemaps: Structure-aware multi-scale navigation techniques. TVCG 13, 1248–1253 (2007)

    Google Scholar 

  17. Holten, D.: Hierarchical edge bundles: Visualization of adjacency relations in hierarchical data. IEEE Transactions on Visualization and Computer Graphics 12(5), 741–748 (2006)

    Article  Google Scholar 

  18. Gansner, E.R., Hu, Y., North, S.C., Scheidegger, C.E.: Multilevel agglomerative edge bundling for visualizing large graphs. In: Battista, G.D., Fekete, J.D., Qu, H. (eds.) Proce. of PacificVis, pp. 187–194. IEEE Computer Society (2011)

    Google Scholar 

  19. Hurter, C., Ersoy, O., Telea, A.: Graph bundling by kernel density estimation. Comp. Graph. Forum 31, 865–874 (2012)

    Article  Google Scholar 

  20. Fruchterman, T., Reingold, E.: Graph drawing by force-directed placement. Software Practice and Experience 21(11), 1129–1164 (1991)

    Article  Google Scholar 

  21. Bostock, M.: Sticky force layout. Online visualization tool, http://bl.ocks.org/mbostock/3750558 (accessed on May 20, 2014)

  22. EBI: Ensemble. Online web page (2014) (accessed on May 20, 2014)

    Google Scholar 

  23. Weaver, C., Bruns, C., Helvensteijn, M.: SharkViewer. Howard Hughes Medical Institute, Janelia Farm Research Campus. doi:10.5281/zenodo.10053 (2014)

    Google Scholar 

  24. Magnenat-Thalmann, N., Ratib, O., Choi, H.F. (eds.): 3D Multiscale Physiological Human. Springer (2014)

    Google Scholar 

  25. Magnenat-Thalmann, N. (ed.): 3DPH 2009. LNCS, vol. 5903. Springer, Heidelberg (2009)

    Google Scholar 

  26. Burger, A., Davidson, D., Baldock, R. (eds.): Anatomy Ontologies for Bioinformatics. Computational Biology, vol. 6. Springer (2008)

    Google Scholar 

  27. Burch, M., Diehl, S.: Trees in a treemap: Visualizing multiple hierarchies. In: Proc. VDA 2006 (2006)

    Google Scholar 

  28. Battista, G.D., Eades, P., Tamassia, R., Tollis, I.G.: Graph Drawing: Algorithms for the Visualization of Graphs. Prentice Hall (1999)

    Google Scholar 

  29. Holten, D., van Wijk, J.J.: Force-directed edge bundling for graph visualization. Comput. Graph. Forum 28(3), 983–990 (2009)

    Article  Google Scholar 

  30. Selassie, D., Heller, B., Heer, J.: Divided edge bundling for directional network data. IEEE Trans. Visualization & Comp. Graphics (Proc. InfoVis) (2011)

    Google Scholar 

  31. Hunter, P., et al.: A vision and strategy for the virtual physiological human in 2010 and beyond. Philos. Trans. A Math. Phys. Eng. Sci. 368(2010), 2595–2614 (1920)

    Google Scholar 

  32. Wikipedia: Zygote body (2014), http://en.wikipedia.org/wiki/Zygote_Body (accessed on May 20, 2014)

  33. de Bono, B., Hunter, P.: Integrating knowledge representation and quantitative modelling in physiology. Biotechnol. J. 7(8), 958–972 (2012)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer International Publishing Switzerland

About this paper

Cite this paper

de Bono, B., Grenon, P., Helvensteijn, M., Kok, J., Kokash, N. (2014). ApiNATOMY: Towards Multiscale Views of Human Anatomy. In: Blockeel, H., van Leeuwen, M., Vinciotti, V. (eds) Advances in Intelligent Data Analysis XIII. IDA 2014. Lecture Notes in Computer Science, vol 8819. Springer, Cham. https://doi.org/10.1007/978-3-319-12571-8_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-12571-8_7

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12570-1

  • Online ISBN: 978-3-319-12571-8

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics