[go: up one dir, main page]

Skip to main content

Machine Learning for Survival Analysis: A Case Study on Recurrence of Prostate Cancer

  • Conference paper
  • First Online:
Artificial Intelligence in Medicine (AIMDM 1999)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 1620))

Abstract

This paper deals with the problem of learning prognostic models from medical survival data, where the sole prediction of probability of event (and not its probability dependency on time) is of interest. To appropriately consider the follow-up time and censoring — both characteristic for survival data — we propose a weighting technique that lessens the impact of data from patients for which the event did not occur and have short follow-up times. A case study on prostate cancer recurrence shows that by incorporating this weighting technique the machine learning tools stand beside or even outperform modern statistical methods and may, by inducing symbolic recurrence models, provide further insight to relationships within the modeled data.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. R. Agrawal, T. Imielinski, and A. Swami. Mining association rules between sets of items in large databases. In Proc. ACM SIGMOD Conference on Management of Data, pages 207–216, Washington, D. C., 1993.

    Google Scholar 

  2. E. Biganzoli, P. Boracchi, and L. Mariani, et al. Feed forward neural networks for the analysis of censored survival data: a partial logistic regression approach. Statis Med, 1998.

    Google Scholar 

  3. D. R. Cox. Regression models and life-tables. J R Statist Soc B, 34:187–220, 1972.

    MATH  Google Scholar 

  4. F. E. Harrell, R. M. Califf, D. B. Pryor, K. L. Lee, and R. A. Rosati. Evaluating the yield of medical tests. Journal of American Medical Association, 247(18):2543–2546, 1982.

    Article  Google Scholar 

  5. M. W. Kattan, H. Ishida, P. T. Scardino, and J. R. Beck. Applying a neural network to prostate cancer survival data. In N. Lavrač, E. Keravnou, and B. Zupan, editors, Intelligent data analysis in medicine and pharmacology, pages 295–306. Kluwer, Boston, 1997.

    Google Scholar 

  6. J. Lubsen, J. Pool, and E. van der Does. A practical device for the application of a diagnostic or prognostic function. Methods of Information in Medicine, 17:127–129, 1978.

    Google Scholar 

  7. D. Michie, D. J. Spiegelhalter, and C. C. Taylor, editors. Machine learning, neural and statistical classification. Ellis Horwood, 1994.

    Google Scholar 

  8. T. Niblett and I. Bratko. Learning decision rules in noisy domains. In Expert Systems 86, pages 15–18. Cambridge University Press, 1986. (Proc. EWSL 1986, Brighton).

    Google Scholar 

  9. M. Ohori, T. M. Wheeler, and P. T. Scardino. The new american joint committee on cancer and international union against cancer tnm classification of prostate cancer: Clinicopathologic correlations. Cancer, 74:104–114, 94.

    Google Scholar 

  10. R. Quinlan. Induction of decision trees. Machine Learning, 1(1):81–106, 1986.

    Google Scholar 

  11. B. D. Ripley and R. M. Ripley. Neural networks as statistical methods in survival analysis. In R. Dybowski and V. Gant, editors, Artificial Neural Networks: Prospects for Medicine. Landes Biosciences Publishers, 1998.

    Google Scholar 

  12. T. M. Therneau, P. M. Grambsch, and T. R. Fleming. Martingale-based residuals for survival models. Biometrika, 77(1):147–160, 1990.

    Article  MATH  MathSciNet  Google Scholar 

  13. W. N. Venables and B. D. Ripley. Modern applied statistics with S-PLUS. Springer, New York, second edition edition, 1997.

    MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Zupan, B., Demšar, J., Kattan, M.W., Beck, J.R., Bratko, I. (1999). Machine Learning for Survival Analysis: A Case Study on Recurrence of Prostate Cancer. In: Horn, W., Shahar, Y., Lindberg, G., Andreassen, S., Wyatt, J. (eds) Artificial Intelligence in Medicine. AIMDM 1999. Lecture Notes in Computer Science(), vol 1620. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-48720-4_37

Download citation

  • DOI: https://doi.org/10.1007/3-540-48720-4_37

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66162-7

  • Online ISBN: 978-3-540-48720-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics