Lothian Birth Cohorts
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The Lothian Birth Cohorts (LBC) of 1921 and 1936 are follow-up studies of the Scottish Mental Surveys of 1932 and 1947. The surveys had, respectively, tested the intelligence of almost every child born in 1921 or 1936 and attending school in Scotland in the month of June in those years. Therefore, tracing, recruiting and re-testing people who had taken part in the Surveys offered a rare opportunity to examine the distribution and causes of cognitive ageing across most of the human life course. The studies described here were initially set up to study determinants of non-pathological cognitive ageing; i.e. the ageing of cognitive functions largely in the normal range, and not principally dementia or other pathological cognitive disorders.
Items in this Collection
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Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life
Genome-wide summary data for the publication of "Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life". -
A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data
Data Supporting the paper de la Fuente, J et al. "A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data" https://doi.org/10.1038/s41562-020-00936-2 . All files are plain text. -
Genome-wide association studies identify 137 loci for DNA methylation biomarkers of aging
These files contain summary statistics for meta-analysis GWAS of six traits in European, African and Trans-Ancestry. There are 18 files in total - 6 for each ancestry by 3 for each trait. The traits are DNA methylation ... -
Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults - OSCA EWAS Proteins
This dataset represents one of five datasets which correspond to the study: "Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults". These datasets represent association ... -
Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults - BayesR+ EWAS Proteins
This dataset represents one of five datasets which correspond to the study: "Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults". These datasets represent association ... -
Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults - Linear Regression EWAS Proteins
This dataset represents one of five datasets which correspond to the study: "Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults". These datasets represent association ... -
Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults - Linear Regression GWAS Proteins
This dataset represents one of five datasets which correspond to the study: "Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults". These datasets represent association ... -
Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income
Data in support of manuscript : Hill, W.D. et al. (2019). Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income. Nature Communications. -
Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936 - GWAS Proteins
Data supporting the paper Hillary, R et al. "Genome and epigenome wide studies of neurological etc" https://doi.org/10.1038/s41467-019-11177-x . Specifically: GWAS proteins (Genome Wide Association Study). -
Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936 - EWAS
Data supporting the paper Hillary et al. "Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936" (In submission). Specifically EWAS proteins. -
SUPERSEDED - Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936 - GWAS Proteins
## THIS ITEM HAS BEEN REPLACED BY THE ONE WHICH CAN BE FOUND AT https://doi.org/10.7488/ds/2612 ## Data supporting the paper Hillary, R, McCartney, DL, Harris, S, Stevenson, A, Seeboth, A, Zhang, Q, Liewald, D, Evans, ... -
Marioni_et_al_AD_GWAS_Sumstats_June2019_Correction - Data supporting Marioni et al. "GWAS on family history of Alzheimer's disease"
Data supporting the paper: Marioni, RE, Harris, SE, Zhang, Q, Mcrae, AF, Hagenaars, SP, Hill, WD, Davies, G, Ritchie, CW, Gale, CR, Starr, JM, Goate, AM, Porteous, DJ, Yang, J, Evans, KL, Deary, IJ, Wray, NR & Visscher, ... -
'DAVIES_NC_2018' - Data supporting paper Davies et al. "Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function."
Data supporting paper Davies et al. "Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function." Nature Communications DOI: 10.1038/s41467-018-04362-x . UK Biobank only ... -
Data supporting Luciano et al. The influence of X chromosome variants on trait neuroticism.
Data supporting the paper Luciano M, Davies G, Summers KM, Hill WD, Hayward C, Liewald DC, Porteous DJ, Gale CR, McIntosh AM, Deary IJ (2019) The influence of X chromosome variants on trait neuroticism. Molecular Psychiatry ... -
Data supporting Hagenaars & Hill et al. Genetic prediction of male pattern baldness. PLOS Genetics
Data supporting the paper Hagenaars & Hill et al. "Genetic prediction of male pattern baldness". PLOS Genetics (2017). doi: 10.1371/journal.pgen.1006594. ## Note re working with data ## The file "Hagenaars2017_UKB_M ... -
Data supporting Luciano et al. Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism
Data supporting the paper Luciano et al. Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism. Nature Genetics (2017). doi: 10.1038/s41588-017-0013-8 -
Data supporting Deary & Hagenaars et al. Genetic contributions to self-reported tiredness
Data supporting the paper Deary & Hagenaars et al. Genetic contributions to self-reported tiredness. Molecular Psychiatry (2017). doi:10.1038/mp.2017.5. -
Data supporting paper Harris et al. "Molecular genetic contributions to self-rated health"
Data supporting paper Harris et al. "Molecular genetic contributions to self-rated health" (International Journal of Epidemiology) -
"Davies2018_OPEN_DATASET_summary_results.txt" - Data supporting paper Davies et al. "Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function."
Data supporting paper Davies et al "Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function." Nature Communications DOI: 10.1038/s41467-018-04362-x . Open dataset summary ... -
"DAVIES_MP_2016.zip" - Data supporting Davies et al. Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151).
Data supporting the paper Davies et al. Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151). Molecular Psychiatry (2016). ## Note re working with data ## Each ...
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