Phylogenetic analyses based on defined proteins or different RNA species have revealed that the o... more Phylogenetic analyses based on defined proteins or different RNA species have revealed that the order kinetoplastida belongs to the early-branching eukaryotes and may thus contain organisms in which complex cellular events are easier to analyze. This view was further supported by results from a bioinformatic survey that suggested that nearly half of the autophagy-related proteins existent in yeast are missing in trypanosomatids. On the other hand, these organisms have evolved a highly sophisticated machinery to escape from the different host immune-response strategies and have learned to cope with extremely variable environmental conditions by morphological and functional reorganization of the cell. For both the stress response and the differentiation processes, autophagy seems to be an indispensable prerequisite. So far autophagy has not been systematically investigated in trypanosomatids. Here we present technical information on how to handle the different parasites belonging to this order and give an overview of the current status of autophagy research in these organisms.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Members of the genus Trypanosoma cause African trypanosomiasis in humans and animals in Africa. I... more Members of the genus Trypanosoma cause African trypanosomiasis in humans and animals in Africa. Infection of mammals by African trypanosomes is characterized by an upregulation of prostaglandin (PG) production in the plasma and cerebrospinal fluid. These metabolites of arachidonic acid (AA) may, in part, be responsible for symptoms such as fever, headache, im- munosuppression, deep muscle hyperaesthesia, miscarriage, ovarian dysfunction,
A xylanase gene, xynA, which encodes xylanase I of Aeromonas caviae ME-1, was cloned in Escherich... more A xylanase gene, xynA, which encodes xylanase I of Aeromonas caviae ME-1, was cloned in Escherichia coli. xynA gene has a 633 bp open reading frame (encoding 211 amino acid residues) which includes a signal peptide (28 amino acid residues). E. coli JM109 transformant produced 0.7 U/ml xylanase, about 80% of which was secreted into the culture medium as mature
Phylogenetic analyses based on defined proteins or different RNA species have revealed that the o... more Phylogenetic analyses based on defined proteins or different RNA species have revealed that the order kinetoplastida belongs to the early-branching eukaryotes and may thus contain organisms in which complex cellular events are easier to analyze. This view was further supported by results from a bioinformatic survey that suggested that nearly half of the autophagy-related proteins existent in yeast are missing in trypanosomatids. On the other hand, these organisms have evolved a highly sophisticated machinery to escape from the different host immune-response strategies and have learned to cope with extremely variable environmental conditions by morphological and functional reorganization of the cell. For both the stress response and the differentiation processes, autophagy seems to be an indispensable prerequisite. So far autophagy has not been systematically investigated in trypanosomatids. Here we present technical information on how to handle the different parasites belonging to this order and give an overview of the current status of autophagy research in these organisms.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Members of the genus Trypanosoma cause African trypanosomiasis in humans and animals in Africa. I... more Members of the genus Trypanosoma cause African trypanosomiasis in humans and animals in Africa. Infection of mammals by African trypanosomes is characterized by an upregulation of prostaglandin (PG) production in the plasma and cerebrospinal fluid. These metabolites of arachidonic acid (AA) may, in part, be responsible for symptoms such as fever, headache, im- munosuppression, deep muscle hyperaesthesia, miscarriage, ovarian dysfunction,
A xylanase gene, xynA, which encodes xylanase I of Aeromonas caviae ME-1, was cloned in Escherich... more A xylanase gene, xynA, which encodes xylanase I of Aeromonas caviae ME-1, was cloned in Escherichia coli. xynA gene has a 633 bp open reading frame (encoding 211 amino acid residues) which includes a signal peptide (28 amino acid residues). E. coli JM109 transformant produced 0.7 U/ml xylanase, about 80% of which was secreted into the culture medium as mature
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