Papers by Nailya Bulatova
SPSS file of manuscript data
Bookmarks Related papers MentionsView impact
Jordan Medical Journal, 2016
Bookmarks Related papers MentionsView impact
Jordan Journal of Pharmaceutical Sciences, 2018
OBJECTIVE: This study aimed to examine the effect of circadian rhythm disruption in night-shift w... more OBJECTIVE: This study aimed to examine the effect of circadian rhythm disruption in night-shift workers on systemic biomarkers of inflammation. METHODS Demographic data, clinical parameters and data on working patterns of 126 adult employees were documented. Serum levels of biomarkers were measured by enzymatic assay procedures. RESULTS: Night-shift workers had markedly lower anti-inflammatory IL-10 and cardioprotective adiponectin and MCP-1 compared to daytime workers. Night-shift workers’ MIF, LAR, TNF-α and TNF-α/IL-10 ratio were significantly higher than those in day shift workers. Spearman's correlation showed that MIF, TNF-α, LAR and TNF-α/IL-10 ratios were positively and significantly correlated with both the duration of the night shift and total number of shifts (p < 0.05). Meanwhile, IL-10, adiponectin and MCP-1 were negatively and significantly correlated with both variables (p < 0.05). CONCLUSION: Night shift work may be closely associated with a higher propensi...
Bookmarks Related papers MentionsView impact
PLOS ONE, Oct 20, 2022
Bookmarks Related papers MentionsView impact
Diabetes & metabolic syndrome, 2018
BACKGROUND Sirtuin 1 (SIRT 1) and malondialdehyde (MDA) were implicated in metabolic syndrome (Me... more BACKGROUND Sirtuin 1 (SIRT 1) and malondialdehyde (MDA) were implicated in metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) pathophysiology. AIMS AND METHODS This cross-sectional study aimed to investigate both SIRT 1 and MDA in 30 lean healthy control, 31 normoglycemic MetS subjects and 30 MetS-Pre/T2DM drug naïve. C orrelation studies were established for both biomarkers with adiposity indices [conicity index (CI), waist circumference (WC), weight-to-height (WHtR) ratio, weight-to-hip (WHR) ratio, hip circumference (HC), and body adiposity index (BAI)], hematological indices [red cell distribution width (RDW), mean platelet volume (MPV), platelet-to-lymphcyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR)] and atherogenicity indices (atherogenicity index of plasma (AIP = log10TG/HDL-C ratio), TC/HDL-C and LDL-C/HDL-C ratios]. RESULTS SIRT1 levels (ng/mL) were markedly lower in both MetS groups (2.12 ± 0.06 and 2.32 ± 0.19, respec...
Bookmarks Related papers MentionsView impact
Bratislava Medical Journal, 2019
Bookmarks Related papers MentionsView impact
Metabolites
Metabolic syndrome (MetS) is a disorder characterized by a group of factors that can increase the... more Metabolic syndrome (MetS) is a disorder characterized by a group of factors that can increase the risk of chronic diseases, including cardiovascular diseases and type 2 diabetes mellitus (T2D). Metabolomics has provided new insight into disease diagnosis and biomarker identification. This cross-sectional investigation used an untargeted metabolomics-based technique to uncover metabolomic alterations and their relationship to pathways in normoglycemic and prediabetic MetS participants to improve disease diagnosis. Plasma samples were collected from drug-naive prediabetic MetS patients (n = 26), normoglycemic MetS patients (n = 30), and healthy (normoglycemic lean) subjects (n = 30) who met the inclusion criteria for the study. The plasma samples were analyzed using highly sensitive ultra-high-performance liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC-ESI-QTOF-MS). One-way ANOVA analysis revealed that 59 metabolites differed significan...
Bookmarks Related papers MentionsView impact
Medicine
RATIONALE The occurrence of subacute thyroiditis (SAT) after vaccines or after hyaluronic acid sk... more RATIONALE The occurrence of subacute thyroiditis (SAT) after vaccines or after hyaluronic acid skin fillers is very rare and might be related to genetic susceptibility. We suggest that the co-administration of both products could potentially increase the possibility of development of SAT. PATIENT CONCERNS A 58-year-old Caucasian healthy female initially presented with chills, myalgia, dysphagia, sore throat, dry cough, fatigue, and intermittent fever of 38.5°C orally after simultaneous injection of an influenza vaccine and a dermal filler containing hyaluronic acid. Ten days later the patient developed palpitations and neck pain radiating to the left jaw. DIAGNOSIS AND INTERVENTIONS She was diagnosed with SAT on day 16 after her first visit and responded promptly to etoricoxib treatment. OUTCOMES The patient progressed clinically from hyperthyroidism to euthyroid state and eventually to hypothyroidism and further testing showed she had HLA B-35 haplotype. LESSONS Physicians should be aware that SAT might be associated with the administration an influenza vaccine and this possible association might increase if the vaccine was co-administered with a dermal filler.
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
ALPHA PSYCHIATRY, 2021
Bookmarks Related papers MentionsView impact
International Journal of Diabetes in Developing Countries
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Medicine
RATIONALE The occurrence of subacute thyroiditis (SAT) after vaccines or after hyaluronic acid sk... more RATIONALE The occurrence of subacute thyroiditis (SAT) after vaccines or after hyaluronic acid skin fillers is very rare and might be related to genetic susceptibility. We suggest that the co-administration of both products could potentially increase the possibility of development of SAT. PATIENT CONCERNS A 58-year-old Caucasian healthy female initially presented with chills, myalgia, dysphagia, sore throat, dry cough, fatigue, and intermittent fever of 38.5°C orally after simultaneous injection of an influenza vaccine and a dermal filler containing hyaluronic acid. Ten days later the patient developed palpitations and neck pain radiating to the left jaw. DIAGNOSIS AND INTERVENTIONS She was diagnosed with SAT on day 16 after her first visit and responded promptly to etoricoxib treatment. OUTCOMES The patient progressed clinically from hyperthyroidism to euthyroid state and eventually to hypothyroidism and further testing showed she had HLA B-35 haplotype. LESSONS Physicians should be aware that SAT might be associated with the administration an influenza vaccine and this possible association might increase if the vaccine was co-administered with a dermal filler.
Bookmarks Related papers MentionsView impact
INTRODUCTION This study aimed to evaluate the effects of single nucleotide polymorphisms CYP3A4*1... more INTRODUCTION This study aimed to evaluate the effects of single nucleotide polymorphisms CYP3A4*1B and CYP3A5*3 on tacrolimus dose requirement among kidney transplant recipients. MATERIALS AND METHODS Blood levels of tacrolimus were measured using microparticle enzyme immunoassay. Genotyping analysis utilized specific polymerase chain reaction-restriction fragment length polymorphism methods for 137 kidney transplant recipients. RESULTS The median tacrolimus dose was significantly lower in the CYP3A4*1/*1 carriers (0.06 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d) as compared to the CYP3A4*1B/*1B carriers (0.1 mg/kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d; P = .001). Patients with at least 1 CYP3A5*1 wild-type allele required higher median doses of tacrolimus (median, 0.08 mg/kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d) as compared to the CYP3A5*3 carriers (median, 0.05 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d; P = .002). CONCLUSIONS This study showed that tacrolimus dose requi...
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
ALPHA PSYCHIATRY, 2021
Bookmarks Related papers MentionsView impact
Background and aims: Oxytocin (OXT), hepatocyte growth factor (HGF) and fibroblast growth factor-... more Background and aims: Oxytocin (OXT), hepatocyte growth factor (HGF) and fibroblast growth factor-21 (FGF-21) were shown to play key roles in different aspects of metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). Nevertheless, how OXT correlates – if at all - with the plasma levels of both FGF-21, and HGF is still to be investigated in MetS-pre/T2DM patients. Methods: In a cross-sectional study, 85 MetS-normoglycemic (control) and 90 MetS-preT2DM patients (BMI-, gender- and age-matched) were enrolled. Plasma OXT levels were measured using competitive binding enzyme-linked immunosorbent assay (ELISA), while FGF-21 and HGF levels were measured using sandwich ELISA. The correlations between these biomarkers and between biomarkers and patients’ clinical parameters such as HbA1c, FPG, blood pressure, lipid profile, and body mass index were evaluated. Results: Mean circulating levels of both HGF and FGF-21 were substantially higher in the MetS-pre/T2DM group than in the MetS-c...
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
INTRODUCTION This study aimed to evaluate the effects of single nucleotide polymorphisms CYP3A4*1... more INTRODUCTION This study aimed to evaluate the effects of single nucleotide polymorphisms CYP3A4*1B and CYP3A5*3 on tacrolimus dose requirement among kidney transplant recipients. MATERIALS AND METHODS Blood levels of tacrolimus were measured using microparticle enzyme immunoassay. Genotyping analysis utilized specific polymerase chain reaction-restriction fragment length polymorphism methods for 137 kidney transplant recipients. RESULTS The median tacrolimus dose was significantly lower in the CYP3A4*1/*1 carriers (0.06 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d) as compared to the CYP3A4*1B/*1B carriers (0.1 mg/kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d; P = .001). Patients with at least 1 CYP3A5*1 wild-type allele required higher median doses of tacrolimus (median, 0.08 mg/kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d) as compared to the CYP3A5*3 carriers (median, 0.05 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d; P = .002). CONCLUSIONS This study showed that tacrolimus dose requi...
Bookmarks Related papers MentionsView impact
Background and aims: Oxytocin (OXT), hepatocyte growth factor (HGF) and fibroblast growth factor-... more Background and aims: Oxytocin (OXT), hepatocyte growth factor (HGF) and fibroblast growth factor-21 (FGF-21) were shown to play key roles in different aspects of metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). Nevertheless, how OXT correlates – if at all - with the plasma levels of both FGF-21, and HGF is still to be investigated in MetS-pre/T2DM patients. Methods: In a cross-sectional study, 85 MetS-normoglycemic (control) and 90 MetS-preT2DM patients (BMI-, gender- and age-matched) were enrolled. Plasma OXT levels were measured using competitive binding enzyme-linked immunosorbent assay (ELISA), while FGF-21 and HGF levels were measured using sandwich ELISA. The correlations between these biomarkers and between biomarkers and patients’ clinical parameters such as HbA1c, FPG, blood pressure, lipid profile, and body mass index were evaluated. Results: Mean circulating levels of both HGF and FGF-21 were substantially higher in the MetS-pre/T2DM group than in the MetS-c...
Bookmarks Related papers MentionsView impact
Uploads
Papers by Nailya Bulatova