SFMBT1
Scm-liki protein 1 sa četiri domena mbt jest protein koji je kod ljudi kodiran genom SFMBT1 sa hromosoma 3.[5]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 866 aminokiselina, а molekulska težina 98.141 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MNGEQQLDAD | AGSGMEEVEL | SWEDYLEETG | STAVPYGSFK | HVDTRLQNGF | ||||
| APGMKLEVAV | RTDPETYWVA | TVITTCEQLL | LLRYDGYGED | RRADFWCDIR | ||||
| KADLYPIGWC | EQNKKTLEAP | EGIRDKVSDW | DEFLRQTLIG | ACSPPVPLLE | ||||
| GLRNGRNPLD | LIAPGSRLEC | QAFQDSLSTW | IVTVVENIGG | RLKLRYEGLE | ||||
| SSDNYEHWLY | YLDPFLHHVG | WAAQQGYELQ | PPSAIRHLKN | EAEWQEILAK | ||||
| VKEEEEEPLP | SYLFKDKQVI | GIHTFSVNMK | LEAVDPWSPF | GISPATVVKV | ||||
| FDEKYFLVEM | DDLRPENHAR | RSFVCHADSP | GIFPVQWSLK | NGLHISPPPG | ||||
| YPSQDFDWAD | YLKQCGAEAA | PQRCFPPLIS | EHEFKENMKL | EAVNPILPEE | ||||
| VCVATITAVR | GSYLWLQLEG | SKKPIPECIV | SVESMDIFPL | GWCETNGHPL | ||||
| STPRRARVYK | QRKIAVVQPE | KQVPSSRTVH | EGLRNQELNS | TESVMINGKY | ||||
| CCPKIYFNHR | CFSGPYLNKG | RIAELPQCVG | PGNCVLVLRE | VLTLLINAAY | ||||
| KPSRVLRELQ | LDKDSVWHGC | GEVLKAKYKG | KSYRATVEIV | KTADRVTEFC | ||||
| RQTCIKLECC | PNLFGPRMVL | DKCSENCSVL | TKTKYTHYYG | KKKNKRIGRP | ||||
| PGGHSNLACA | LKKASKRRKR | RKNVFVHKKK | RSSASVDNTP | AGSPQGSGGE | ||||
| DEDDPDEGDD | DSLSEGSTSE | QQDELQEESE | MSEKKSCSSS | PTQSEISTSL | ||||
| PPDRQRRKRE | LRTFSFSDDE | NKPPSPKEIR | IEVAERLHLD | SNPLKWSVAD | ||||
| VVRFIRSTDC | APLARIFLDQ | EIDGQALLLL | TLPTVQECMD | LKLGPAIKLC | ||||
| HHIERIKFAF | YEQFAN |
Funkcija
urediOvaj gen ima veliku sličnost sa genom Scm Drosophila (spolni češalj na srednjoj nozi). Kodira protein koji sadrži četiri ponavljajuća domena malignog tumoa mozga (mbt) i može biti uključen u prepoznavanje antigena (prema RefSeq, juni 2012).
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000163935 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006527 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Scm-like with four mbt domains 1". Pristupljeno 22. 11. 2013.
- ^ "UniProt, Q9UHJ3" (jezik: engleski). Pristupljeno 5. 11. 2021.
Dopunska literatura
uredi- Zhang, J.; Bonasio, R.; Strino, F.; Kluger, Y.; Holloway, J. K.; Modzelewski, A. J.; Cohen, P. E.; Reinberg, D. (2013). "SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors". Genes & Development. 27 (7): 749–766. doi:10.1101/gad.210963.112. PMC 3639416. PMID 23592795.
- Köttgen, A.; Albrecht, E.; Teumer, A.; Vitart, V.; Krumsiek, J.; Hundertmark, C.; Pistis, G.; Ruggiero, D.; O'Seaghdha, C. M.; Haller, T.; Yang, Q.; Tanaka, T.; Johnson, A. D.; Kutalik, Z. N.; Smith, A. V.; Shi, J.; Struchalin, M.; Middelberg, R. P. S.; Brown, M. J.; Gaffo, A. L.; Pirastu, N.; Li, G.; Hayward, C.; Zemunik, T.; Huffman, J.; Yengo, L.; Zhao, J. H.; Demirkan, A.; Feitosa, M. F.; et al. (2012). "Genome-wide association analyses identify 18 new loci associated with serum urate concentrations". Nature Genetics. 45 (2): 145–154. doi:10.1038/ng.2500. PMC 3663712. PMID 23263486.
- Kato, T.; Sato, H.; Emi, M.; Seino, T.; Arawaka, S.; Iseki, C.; Takahashi, Y.; Wada, M.; Kawanami, T. (2011). "Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly: A community-based study". Internal Medicine (Tokyo, Japan). 50 (4): 297–303. doi:10.2169/internalmedicine.50.4505. PMID 21325761.
- Lin, S.; Shen, H.; Li, J. -L.; Tang, S.; Gu, Y.; Chen, Z.; Hu, C.; Rice, J. C.; Lu, J.; Wu, L. (2013). "Proteomic and Functional Analyses Reveal the Role of Chromatin Reader SFMBT1 in Regulating Epigenetic Silencing and the Myogenic Gene Program". Journal of Biological Chemistry. 288 (9): 6238–6247. doi:10.1074/jbc.M112.429605. PMC 3585059. PMID 23349461.
- Wu, S.; Trievel, R. C.; Rice, J. C. (2007). "Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3". FEBS Letters. 581 (17): 3289–3296. doi:10.1016/j.febslet.2007.06.025. PMC 2045647. PMID 17599839.
- Yang, H. C.; Liang, Y. J.; Chen, J. W.; Chiang, K. M.; Chung, C. M.; Ho, H. Y.; Ting, C. T.; Lin, T. H.; Sheu, S. H.; Tsai, W. C.; Chen, J. H.; Leu, H. B.; Yin, W. H.; Chiu, T. Y.; Chern, C. I.; Lin, S. J.; Tomlinson, B.; Guo, Y.; Sham, P. C.; Cherny, S. S.; Lam, T. H.; Thomas, G. N.; Pan, W. H. (2012). Mariño-Ramírez, Leonardo (ured.). "Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as Hypertension Susceptibility Genes in Han Chinese with a Genome-Wide Gene-Based Association Study". PLOS ONE. 7 (3): e32907. Bibcode:2012PLoSO...732907Y. doi:10.1371/journal.pone.0032907. PMC 3315540. PMID 22479346.
- Morel, S.; Lévy, F.; Burlet-Schiltz, O.; Brasseur, F.; Probst-Kepper, M.; Peitrequin, A. L.; Monsarrat, B.; Van Velthoven, R.; Cerottini, J. C.; Boon, T.; Gairin, J. E.; Van Den Eynde, B. J. (2000). "Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells". Immunity. 12 (1): 107–117. doi:10.1016/S1074-7613(00)80163-6. PMID 10661410.
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.