HLA-DRA

DR alfa-lanac HLA klase II antigena histokompatibilnosti jest protein koji je kod ljudi kodiran genom HLA-DRA. HLA-DRA kodira alfa podjedinicu HLA-DR. Za razliku od alfa lanaca drugih ljudskih molekula kompleksne klase II MHC, alfa podjedinica je praktično nepromjenjiva. Međutim, može se upariti sa, u bilo koje osobe, beta-lancem iz tri različita DR beta lokusa, DRB1 i dva bilo koja od DRB3, aleli DRB4 ili DRB5. Stoga postoji potencijal da bilo koja osoba može formirati četiri različite HLA-DR izoforme (po dva alela DRB1 i DRB3, DRB4 ili DRB5).

HLA-DRA
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1A6A, 1AQD, 1BX2, 1D5M, 1D5X, 1D5Z, 1D6E, 1DLH, 1FV1, 1FYT, 1H15, 1HXY, 1J8H, 1JWM, 1JWS, 1JWU, 1KG0, 1KLG, 1KLU, 1LO5, 1PYW, 1R5I, 1SEB, 1SJE, 1SJH, 1T5W, 1T5X, 1YMM, 1ZGL, 2FSE, 2G9H, 2IAM, 2IAN, 2ICW, 2IPK, 2OJE, 2Q6W, 2WBJ, 2XN9, 3C5J, 3L6F, 3O6F, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 3S4S, 3S5L, 3T0E, 4AEN, 4AH2, 4E41, 4FQX, 4GBX, 4H1L, 4C56, 4H25, 4H26, 4I5B, 4IS6, 4MCY, 4MCZ, 4MD0, 4MD4, 4MD5, 4MDI, 4MDJ, 4OV5, 4Y19, 4Y1A, 4X5X, 4X5W
Identifikatori
Aliasi	HLA-DRA
Vanjski ID-jevi	OMIM: 142860 MGI: 95900 HomoloGene: 7751 GeneCards: HLA-DRA
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek) Bend 6p21.32 Početak 32,439,878 bp Kraj 32,445,046 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • peptide antigen binding • MHC class II receptor activity • MHC class II protein complex binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endozom • Golđijev aparat • trans-Golgi network membrane • endoplasmic reticulum membrane • membrana • late endosome membrane • Golđijeva membrana • ćelijska membrana • transport vesicle membrane • integral component of plasma membrane • cell surface • lysosomal membrane • Endoplazmatski retikulum • ER to Golgi transport vesicle membrane • Lizozom • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane • Egzosom • MHC class II protein complex Biološki proces • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • kognitivna funkcija • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • peptide antigen assembly with MHC class II protein complex • GO:0022415 viral process • T cell receptor signaling pathway • adaptive immune response Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3122	100504404
Ensembl	ENSG00000206308 ENSG00000228987 ENSG00000230726 ENSG00000204287 ENSG00000227993 ENSG00000226260 ENSG00000234794 ENSG00000277263	ENSMUSG00000036322
UniProt	P01903	P04224 P01904
RefSeq (mRNK)	NM_019111	NM_010381
RefSeq (bjelančevina)	NP_061984	NP_034511
Lokacija (UCSC)	Chr 6: 32.44 – 32.45 Mb	n/a
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 254 aminokiseline, а molekulska težina Da. 28 607

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAISGVPVLG		FFIIAVLMSA		QESWAIKEEH		VIIQAEFYLN		PDQSGEFMFD
FDGDEIFHVD		MAKKETVWRL		EEFGRFASFE		AQGALANIAV		DKANLEIMTK
RSNYTPITNV		PPEVTVLTNS		PVELREPNVL		ICFIDKFTPP		VVNVTWLRNG
KPVTTGVSET		VFLPREDHLF		RKFHYLPFLP		STEDVYDCRV		EHWGLDEPLL
KHWEFDAPSP		LPETTENVVC		ALGLTVGLVG		IIIGTIFIIK		GVRKSNAAER
RGPL

Genska struktura i polimorfizmi

Alfa-lanac je težak približno 33-35 kDa, a njegov gen sadrži pet egzona. Egzon 1 kodira vodeći peptid, egzoni 2 i 3 kodiraju dva vanćelijska domena, a egzon 4 kodira transmembranski domen i citoplazmatski rep. DRA nema polimorfizme u dijelu koji se veže za peptide i djeluje kao jedini alfa-lanac za DRB1, DRB3, DRB4 i DRB5.

Aleli

U ljudskoj populaciji postoje dva različita lanca HLA-DRA, kodirana s tri različita alela DRA:

DRA*01: 01 DRA*01: 02: 01 DRA*01: 02: 02

Funkcija

Polipeptidna podjedinica kodirana ovim genom pripada alfa-lancu HLA klasi II paraloga. Protein klase II je heterodimer koji se sastoji od alfa (DRα) i beta-lanca (DRβ), oba usidrena u membrani. Ima centralnu ulogu u imunskom sistemu predstavljajući peptide izvedene iz vanćelijskih proteina. Molekule klase II su eksprimirane u ćelijama koje prezentiraju antigene (APC: B limfociti, dendritske ćelije, makrofagi).

Također pogledajte

• HLA-DR
• HLA

Dopunska literatura

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