EMCN

EMCN
Identifikatori
Aliasi	EMCN
Vanjski ID-jevi	OMIM: 608350 MGI: 1891716 HomoloGene: 9438 GeneCards: EMCN
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	100,880,126 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	137,137,946 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	51705
	59308
	ENSG00000164035
	ENSMUSG00000054690
	Q9ULC0
	Q9R0H2
	NM_001159694; NM_016242
	NM_001163522; NM_016885
	NP_001153166; NP_057326
	NP_001156994; NP_058581
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Endomucin jest protein koji je kod ljudi kodiran genom EMCN sa hromosoma 4.^[5]^[6]^[7] Endomucin je marker za endolelne^[8] i hematopoetske matične ćelije.^[9]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 261 aminokiselina, а molekulska težina 27.452 Da.^[10]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MELLQVTILF	LLPSICSSNS	TGVLEAANNS	LVVTTTKPSI	TTPNTESLQK
NVVTPTTGTT	PKGTITNELL	KMSLMSTATF	LTSKDEGLKA	TTTDVRKNDS
IISNVTVTSV	TLPNAVSTLQ	SSKPKTETQS	SIKTTEIPGS	VLQPDASPSK
TGTLTSIPVT	IPENTSQSQV	IGTEGGKNAS	TSATSRSYSS	IILPVVIALI
VITLSVFVLV	GLYRMCWKAD	PGTPENGNDQ	PQSDKESVKL	LTVKTISHES
GEHSAQGKTK	N

Funkcija

EMCN je mucinoliki sijaloglikoprotein koji ometa sastavljanje fokusnih adhezijskih kompleksa i inhibira interakciju između ćelija i vanćelijskog matriksa.^[5]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164035 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054690 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (juni 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125. S2CID 23615506.
^ Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (oktobar 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
^ ^a ^b "Entrez Gene: EMCN endomucin".
^ Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288: 129–136. doi:10.1006/bbrc.2001.5737. PMID 11594763.
^ Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC 2213340. PMID 16314436.
^ "UniProt, Q9ULC0" (jezik: engleski). Pristupljeno 25. 10. 2021.

Dopunska literatura

Li G, Miles A, Line A, Rees RC (mart 2004). "Identification of tumour antigens by serological analysis of cDNA expression cloning". Cancer Immunology, Immunotherapy. 53 (3): 139–43. doi:10.1007/s00262-003-0471-y. PMID 14722670. S2CID 10785466.
Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, Böcker W, Vestweber D (maj 2002). "Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope". The American Journal of Pathology. 160 (5): 1669–81. doi:10.1016/S0002-9440(10)61114-5. PMC 1850881. PMID 12000719.
Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (juni 2002). "Serological identification and expression analysis of gastric cancer-associated genes". British Journal of Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D (decembar 2002). "Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin". The Journal of Investigative Dermatology. 119 (6): 1388–93. doi:10.1046/j.1523-1747.2002.19647.x. PMID 12485444.
Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M (septembar 2004). "Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling". International Immunology. 16 (9): 1265–74. doi:10.1093/intimm/dxh128. PMID 15249540.
Reckzeh K.; Kizilkaya H.; Søgaard Helbo A.; Estruch Alrich M.; et al. (2018). "Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin". Blood Advances. 2 (13): 1628–1632. doi:10.1182/bloodadvances.2018015743. PMC 6039657. PMID 29986855.</ref>

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164035 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054690 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Kinoshita_2001-5] Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (juni 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125. S2CID 23615506.

[pmid11594763-6] Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (oktobar 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.

[entrez-7] "Entrez Gene: EMCN endomucin".

[8] Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288: 129–136. doi:10.1006/bbrc.2001.5737. PMID 11594763.

[9] Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC 2213340. PMID 16314436.

[UniProt-10] "UniProt, Q9ULC0" (jezik: engleski). Pristupljeno 25. 10. 2021.

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