AFF3
Član 3 porodice proteina AF4/FMR2 jest protein koji je kod ljudi kodiran genom AFF3 sa hromosoma 3.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 1.226 aminokiselina, а molekulska težina 133.476 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDSFDLALLQ | EWDLESLCVY | EPDRNALRRK | ERERRNQETQ | QDDGTFNSSY | ||||
| SLFSEPYKTN | KGDELSNRIQ | NTLGNYDEMK | DFLTDRSNQS | HLVGVPKPGV | ||||
| PQTPVNKIDE | HFVADSRAQN | QPSSICSTTT | STPAAVPVQQ | SKRGTMGWQK | ||||
| AGHPPSDGQQ | RATQQGSLRT | LLGDGVGRQQ | PRAKQVCNVE | VGLQTQERPP | ||||
| AMAAKHSSSG | HCVQNFPPSL | ASKPSLVQQK | PTAYVRPMDG | QDQAPDESPK | ||||
| LKSSSETSVH | CTSYRGVPAS | KPEPARAKAK | LSKFSIPKQG | EESRSGETNS | ||||
| CVEEIIREMT | WLPPLSAIQA | PGKVEPTKFP | FPNKDSQLVS | SGHNNPKKGD | ||||
| AEPESPDSGT | SNTSMLEDDL | KLSSDEEENE | QQAAQRTALR | ALSDSAVVQQ | ||||
| PNCRTSVPSS | KGSSSSSSSG | SSSSSSDSES | SSGSDSETES | SSSESEGSKP | ||||
| PHFSSPEAEP | ASSNKWQLDK | WLNKVNPHKP | PILIQNESHG | SESNQYYNPV | ||||
| KEDVQDCGKV | PDVCQPSLRE | KEIKSTCKEE | QRPRTANKAP | GSKGVKQKSP | ||||
| PAAVAVAVSA | AAPPPAVPCA | PAENAPAPAR | RSAGKKPTRR | TERTSAGDGA | ||||
| NCHRPEEPAA | ADALGTSVVV | PPEPTKTRPC | GNNRASHRKE | LRSSVTCEKR | ||||
| RTRGLSRIVP | KSKEFIETES | SSSSSSSDSD | LESEQEEYPL | SKAQTVAASA | ||||
| SSGNDQRLKE | AAANGGSGPR | APVGSINART | TSDIAKELEE | QFYTLVPFGR | ||||
| NELLSPLKDS | DEIRSLWVKI | DLTLLSRIPE | HLPQEPGVLS | APATKDSESA | ||||
| PPSHTSDTPA | EKALPKSKRK | RKCDNEDDYR | EIKKSQGEKD | SSSRLATSTS | ||||
| NTLSANHCNM | NINSVAIPIN | KNEKMLRSPI | SPLSDASKHK | YTSEDLTSSS | ||||
| RPNGNSLFTS | ASSSKKPKAD | SQLQPHGGDL | TKAAHNNSEN | IPLHKSRPQT | ||||
| KPWSPGSNGH | RDCKRQKLVF | DDMPRSADYF | MQEAKRMKHK | ADAMVEKFGK | ||||
| ALNYAEAALS | FIECGNAMEQ | GPMESKSPYT | MYSETVELIR | YAMRLKTHSG | ||||
| PNATPEDKQL | AALCYRCLAL | LYWRMFRLKR | DHAVKYSKAL | IDYFKNSSKA | ||||
| AQAPSPWGAS | GKSTGTPSPM | SPNPSPASSV | GSQGSLSNAS | ALSPSTIVSI | ||||
| PQRIHQMAAN | HVSITNSILH | SYDYWEMADN | LAKENREFFN | DLDLLMGPVT | ||||
| LHSSMEHLVQ | YSQQGLHWLR | NSAHLS |
Funkcija
urediOvaj gen kodira tkivno ograničeni jedarni transkripcijski aktivator koji se prvenstveno eksprimira u limfoidnom tkivu. Izolacija ovog proteina je prvobitno definirala visoko konzerviranu porodicu gena LAF4/MLLT2 jedarnih transkripcijskih faktora koji mogu funkcionirati u razvoju limfoida i onkogenezi. Kod nekih pacijenata sa akutnom limfoblastnom leukemijom , ovaj gen je pronađen spojen sa genom za mijeloidnu/limfoidnu ili mešovitu leukemiju. Za ovaj gen je pronađeno više alternativno prerađnih varijanti transkriptakoje kodiraju različite proteinske izoforme.[7]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000144218 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037138 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Liao X, Ma C, Trask B, Massa H, Gilbert DJ, Staudt LM, Jenkins NA, Copeland NG (Jun 1996). "LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12". Mammalian Genome. 7 (6): 467–8. doi:10.1007/s003359900137. PMID 8662235. S2CID 1525532.
- ^ Ma C, Staudt LM (Jan 1996). "LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias". Blood. 87 (2): 734–45. doi:10.1182/blood.V87.2.734.bloodjournal872734. PMID 8555498.
- ^ a b "Entrez Gene: AFF3 AF4/FMR2 family, member 3".
- ^ "UniProt, P51826" (jezik: engleski). Pristupljeno 10. 11. 2021.
Dopunska literatura
uredi- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- von Bergh AR, Beverloo HB, Rombout P, van Wering ER, van Weel MH, Beverstock GC, Kluin PM, Slater RM, Schuuring E (Sep 2002). "LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia". Genes, Chromosomes & Cancer. 35 (1): 92–6. doi:10.1002/gcc.10091. PMID 12203795. S2CID 20750925.
- Hiwatari M, Taki T, Taketani T, Taniwaki M, Sugita K, Okuya M, Eguchi M, Ida K, Hayashi Y (maj 2003). "Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)". Oncogene. 22 (18): 2851–5. doi:10.1038/sj.onc.1206389. PMID 12743608.
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
- To MD, Faseruk SA, Gokgoz N, Pinnaduwage D, Done SJ, Andrulis IL (Jul 2005). "LAF-4 is aberrantly expressed in human breast cancer". International Journal of Cancer. 115 (4): 568–74. doi:10.1002/ijc.20881. PMID 15704140. S2CID 11311219.
Vanjski linkovi
uredi- Lokacija ljudskog genoma AFF3 i stranica sa detaljima o genu AFF3 u UCSC Genome Browseru.