Aminokiselinska sekvenca
uredi
Dužina polipeptidnog lanca je 994 aminokiseline , a molekulska težina 113.415 Da .[ 7]
10 20 30 40 50 MAASFFSDFG LMWYLEELKK EEFRKFKEHL KQMTLQLELK QIPWTEVKKA SREELANLLI KHYEEQQAWN ITLRIFQKMD RKDLCMKVMR ERTGYTKTYQ AHAKQKFSRL WSSKSVTEIH LYFEEEVKQE ECDHLDRLFA PKEAGKQPRT VIIQGPQGIG KTTLLMKLMM AWSDNKIFRD RFLYTFYFCC RELRELPPTS LADLISREWP DPAAPITEIV SQPERLLFVI DSFEELQGGL NEPDSDLCGD LMEKRPVQVL LSSLLRKKML PEASLLIAIK PVCPKELRDQ VTISEIYQPR GFNESDRLVY FCCFFKDPKR AMEAFNLVRE SEQLFSICQI PLLCWILCTS LKQEMQKGKD LALTCQSTTS VYSSFVFNLF TPEGAEGPTP QTQHQLKALC SLAAEGMWTD TFEFCEDDLR RNGVVDADIP ALLGTKILLK YGERESSYVF LHVCIQEFCA ALFYLLKSHL DHPHPAVRCV QELLVANFEK ARRAHWIFLG CFLTGLLNKK EQEKLDAFFG FQLSQEIKQQ IHQCLKSLGE RGNPQGQVDS LAIFYCLFEM QDPAFVKQAV NLLQEANFHI IDNVDLVVSA YCLKYCSSLR KLCFSVQNVF KKEDEHSSTS DYSLICWHHI CSVLTTSGHL RELQVQDSTL SESTFVTWCN QLRHPSCRLQ KLGINNVSFS GQSVLLFEVL FYQPDLKYLS FTLTKLSRDD IRSLCDALNY PAGNVKELAL VNCHLSPIDC EVLAGLLTNN KKLTYLNVSC NQLDTGVPLL CEALCSPDTV LVYLMLAFCH LSEQCCEYIS EMLLRNKSVR YLDLSANVLK DEGLKTLCEA LKHPDCCLDS LCLVKCFITA AGCEDLASAL ISNQNLKILQ IGCNEIGDVG VQLLCRALTH TDCRLEILGL EECGLTSTCC KDLASVLTCS KTLQQLNLTL NTLDHTGVVV LCEALRHPEC ALQVLGLRKT DFDEETQALL TAEEERNPNL TITDDCDTIT RVEI
NALP-i su citoplazmatski proteini koji čine potporodicu unutar veće porodice proteina CATERPILLER. Većina kratkih NALP-ova, kao što je NALP4, ima N-terminal pirin (MEFV; MIM 608107) domen (PYD), praćen NACHT domenom, NACHT-povezanom domenom (NAD) i C-terminalni region ponavljanja bogatog leucinom (LRR).
Dugi NALP, NALP1 (MIM 606636), takođe ima ekstenziju C-terminala koja sadrži funkciju za pronalaženje domena (FIIND) i kaspaza regrutirajući domen (CARD). NALP su uključeni u aktivaciju proopalnih kaspaza (npr. CASP1 ; MIM 147678) kroz njihovo učešće u multiproteinskim kompleksima zvanim Inflamasomi (Tschopp et al., 2003), prema OMIM .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000160505 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034690 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol . 4 (2): 95–104. doi :10.1038/nrm1019 . PMID 12563287 . S2CID 31417018 . ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing" . J Biol Chem . 277 (33): 29874–80. doi :10.1074/jbc.M203915200 PMID 12019269 . ^ a b c "Entrez Gene: NLRP4 NLR family, pyrin domain containing 4" .
Dopunska literatura
uredi
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses" . Biochem. J . 381 (Pt 1): 213–9. doi :10.1042/BJ20031506 . PMC 1133779 PMID 15107016 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Grenier JM, Wang L, Manji GA, et al. (2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett . 530 (1–3): 73–8. doi :10.1016/S0014-5793(02)03416-6 . PMID 12387869 . S2CID 25023390 . Fiorentino L, Stehlik C, Oliveira V, et al. (2002). "A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta" . J. Biol. Chem . 277 (38): 35333–40. doi :10.1074/jbc.M200446200 PMID 12093792 .
Šablon:NOD-likik receptori
