%0 Journal Article
%@ 2561-3278
%I JMIR Publications
%V 10
%N 
%P e65366
%T Cardiac Repair and Regeneration via Advanced Technology: Narrative Literature Review
%A Lee,Yugyung
%A Shelke,Sushil
%A Lee,Chi
%+ Division of Pharmacology and Pharmaceutics Sciences, School of Pharmacy, University of Missouri Kansas City, 5000 Holmes St, Kansas City, MO, 64110, United States, 1 8162352408, leech@umkc.edu
%K advanced technologies
%K genetics
%K biomaterials
%K bioengineering
%K medical devices
%K implantable devices
%K wearables
%K cardiovascular repair and regeneration
%K cardiac care
%K cardiovascular disease
%D 2025
%7 8.3.2025
%9 Review
%J JMIR Biomed Eng
%G English
%X Background: Cardiovascular diseases (CVDs) are the leading cause of death globally, and almost one-half of all adults in the United States have at least one form of heart disease. This review focused on advanced technologies, genetic variables in CVD, and biomaterials used for organ-independent cardiovascular repair systems. Objective: A variety of implantable and wearable devices, including biosensor-equipped cardiovascular stents and biocompatible cardiac patches, have been developed and evaluated. The incorporation of those strategies will hold a bright future in the management of CVD in advanced clinical practice. Methods: This study employed widely used academic search systems, such as Google Scholar, PubMed, and Web of Science. Recent progress in diagnostic and treatment methods against CVD, as described in the content, are extensively examined. The innovative bioengineering, gene delivery, cell biology, and artificial intelligence–based technologies that will continuously revolutionize biomedical devices for cardiovascular repair and regeneration are also discussed. The novel, balanced, contemporary, query-based method adapted in this manuscript defined the extent to which an updated literature review could efficiently provide research on the evidence-based, comprehensive applicability of cardiovascular devices for clinical treatment against CVD. Results: Advanced technologies along with artificial intelligence–based telehealth will be essential to create efficient implantable biomedical devices, including cardiovascular stents. The proper statistical approaches along with results from clinical studies including model-based risk probability prediction from genetic and physiological variables are integral for monitoring and treatment of CVD risk. Conclusions: To overcome the current obstacles in cardiac repair and regeneration and achieve successful therapeutic applications, future interdisciplinary collaborative work is essential. Novel cardiovascular devices and their targeted treatments will accomplish enhanced health care delivery and improved therapeutic efficacy against CVD. As the review articles contain comprehensive sources for state-of-the-art evidence for clinicians, these high-quality reviews will serve as a first outline of the updated progress on cardiovascular devices before undertaking clinical studies. 
%R 10.2196/65366
%U https://biomedeng.jmir.org/2025/1/e65366
%U https://doi.org/10.2196/65366