Papers by Prof. Dr. Mine Ergüven
Bookmarks Related papers MentionsView impact
Anadolu BİL Meslek Yüksekokulu Dergisi, Mar 31, 2019
Kronik myeloid losemi (KML) losemilerin yaklasik dortte birini olusturur ve her 100.000 kisiden 1... more Kronik myeloid losemi (KML) losemilerin yaklasik dortte birini olusturur ve her 100.000 kisiden 1 veya 2’sinde bu hastalik gorulur. Diyetten elde edilen ya da bobrekte, karacigere ve beyindeki lizin ve metioninden endojen olarak sentezlenen bir yardimci faktor olan L-karnitin (LK), uzun zincirli yagli asitlerini (YA’lar), sitrik asit dongusu uzerinden ATP uretimi icin mitokondriyal matrikse tasir. YA’lerinin blokajina bagli olan tedavi uygulamalari ve LK seviyelerindeki dusus, kanser gerilemesine yol acar. Akut miyeloid losemi (AML) dahil olmak uzere cesitli kanser tiplerine tek olarak veya kombinasyon halinde LK uygulanmasi, apoptozun baslatilmasi yoluyla inhibisyon etkisi gosterir. Bununla birlikte LK uzerine, kansere neden oldugu ve kanser hucrelerini uygulanan kemoterapi ve/veya radyoterapi gibi kanser tedavilerinin verdigi zarardan korudugu hakkinda yayinlanmis bazi tartismali calismalar da bulunmaktadir. Bu derlemedeki amacimiz LK’nin etkilerini genel kanser semasi ile birlikte KML yonunden tekrar degerlendirmekti. Diger LK baz alinarak yapilan deneysel ve klinik calismalarin analizleri ve analiz yorumlarina yer verilerek yaptigimiz bu derlemenin sonunda, LK’nin gida takviyesi olarak alinirken veya zayiflamak icin kullanilirken veya tek basina ve/veya coklu kanser tedavilerinde adjuvant terapi ajani olarak kullanilirken LK’nin plazma konsantrasyon seviyeleri, apoptotik ve anti-apoptotik etkileri ile kanserojen olabilen metabolitleri goz onune alinarak kanser olusturma riskine karsi dikkatli olunmasi gerektigi sonucuna varildi.
Bookmarks Related papers MentionsView impact
Acta Neurobiologiae Experimentalis, 2021
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Physiology International, 2017
It has been reported that changes in cytokine levels affect mitochondrial functions, levels of hy... more It has been reported that changes in cytokine levels affect mitochondrial functions, levels of hypoxia-inducible factor α (HIF-1α), and tissue damage during sepsis. We aimed to investigate the effects of simvastatin pretreatment on mitochondrial enzyme activities, and on levels of ghrelin, HIF-1α, and thiobarbituric acid reactive substances (TBARS) in kidney tissue during sepsis. Rats were separated into four groups, namely, control, lipopolysaccharides (LPS) (20 mg/kg), simvastatin (20 mg/kg), and simvastatin + LPS. We measured the levels of mitochondrial enzyme activities and TBARS in the kidney using spectrophotometry. The histological structure of the kidney sections was examined after staining with hematoxylin and eosin. Tumor necrosis factor α (TNF-α), IL-10, HIF-1α, and ghrelin immunoreactivity were examined using proper antibodies. In tissue, TNF-α (p < 0.01) and HIF-1α (p < 0.05) levels were increased in the simvastatin + LPS and LPS groups. TBARS levels were higher i...
Bookmarks Related papers MentionsView impact
Connective Tissue Research, 2017
Bookmarks Related papers MentionsView impact
Nitric Oxide, 2007
1st International Conference on Nitric Oxide and Cancer -- NOV 26-28, 2007 -- Paris, FRANCEWOS: 0... more 1st International Conference on Nitric Oxide and Cancer -- NOV 26-28, 2007 -- Paris, FRANCEWOS: 00025083600006
Bookmarks Related papers MentionsView impact
Fertility and Sterility, 2018
Bookmarks Related papers MentionsView impact
DergiPark (Istanbul University), Jun 1, 2015
Bookmarks Related papers MentionsView impact
DergiPark (Istanbul University), Jun 1, 2011
Bookmarks Related papers MentionsView impact
Türkiye klinikleri tıp bilimleri dergisi, 2011
Bookmarks Related papers MentionsView impact
Human Reproduction
Study question Does hyaluronidase (HAse) have possible negative or positive effects on cumulus ce... more Study question Does hyaluronidase (HAse) have possible negative or positive effects on cumulus cells (CCs) during oocyte denudation before ICSI by altering midkine (MK) levels? Summary answer Hyaluronidase inhibits the proliferation of CCs via the inhibition of MK activity which may result in poor embryo quality and low ICSI success. What is known already MK is abundantly expressed in ovarian follicles. MK secreted from the cumulus-granulosa cells that surround oocytes was shown to promote the cytoplasmic maturation of oocytes. This effect of MK could be mediated via its' anti-apoptotic effect and some other mechanisms. The removal of CCs during oocyte denudation (OD) is done in order to select and grade the oocytes before ICSI. HAse is applied for ICSI to break down hyaluronic acid, which is present at high levels in the cumulus-oocyte complex during OD. To date, there have only been a few reported cases of the toxic effects of hyaluronidase on oocytes. Study design, size, dura...
Bookmarks Related papers MentionsView impact
Human Reproduction, 2021
Is there any relationship between apoptosis rate and progesterone levels in terms of the degree o... more Is there any relationship between apoptosis rate and progesterone levels in terms of the degree of embryo quality and clinical pregnancy success? The cumulus cell apoptosis and progesterone levels measured at the hCG day were associated with embryo quality and clinical pregnancy success. The high rate of apoptosis at cumulus cells led to poor embryo development with the clinical pregnancy failure. It is prospective study carried out with 40 healthy women diagnosed as the male factor between September 2017 and April 2018. 40 healthy women aged between 27–38 and diagnosed as the male factor who were undergoing IVF participated the study. The cumulus cells were taken after denudation and cultured. The rate of the apoptosis were measured using with TUNEL method every 24 hours for 96 hours. In concominant with the apoptosis evaluation, the embryo progession and clinical pregnancy rate were also monitored. Progesterone levels taken at the hCG day were also measured. In this study, it was ...
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Turkish Journal of Biochemistry
Objectives This study aimed to investigate whether a growth factor and a cytokine midkine (MK) ca... more Objectives This study aimed to investigate whether a growth factor and a cytokine midkine (MK) can be a new biomarker for the diagnosis and treatment of unexplained female infertility (UFI) cases. Methods Serum (S), follicle fluid (FF), and cumulus cells (CCs) of the patients aged 20–42 years, diagnosed with male factor (MF) and UFI were used. Patients underwent Intracytoplasmic Sperm Injection (ICSI). The Anti-Müllerian Hormone (AMH) and MK levels with other hormone levels (FSH, LH, E2, PRL, INHB, TSH), the oocyte and embryo qualities, the fertilization and pregnancy rates, and cumulus cells (Cell number and ultrastructure, apoptosis rate) were evaluated. Student-T-test was performed and p<0.05 was considered statistically significant. Results and Discussion The lowest numbers of CCs were found at UFI (p<0.05). The lowest apoptosis rate with the highest CC viability rate was evaluated at MF (p<0.05). The lowest AMH and MK levels (S, FF) were detected at UFI in comparison t...
Bookmarks Related papers MentionsView impact
Oncology Letters, 2016
Bookmarks Related papers MentionsView impact
Neurological research, 2016
Glioblastoma (GBM), the most common primary tumour of the central nervous system, is characterise... more Glioblastoma (GBM), the most common primary tumour of the central nervous system, is characterised by a high malignancy and poor prognosis. The aims of this study were to investigate whether the combination of imatinib mesylate (IM) and lithium chloride (LiCl) exhibited a synergistic effect in treatment and to determine whether midkine (MK) affected the fate of this treatment in vitro. Monolayer and spheroid cultures of the T98G human GBM cell line were treated with an IM and LiCl combination for 72 h. The cell proliferation index, apoptotic index, cell cycle distribution, apoptotic and anti-apoptotic protein levels, and cAMP level as well as the cellular morphology and ultrastructure were evaluated. All applications inhibited cell proliferation and induced apoptosis. The most substantial decreases in cell proliferation and the caspase-3, epidermal growth factor receptor (EGFR), platelet derived growth factor receptor-alpha (PDGFR-α), multidrug resistance protein-1 (MRP-1), aquapori...
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Journal of Gynecologic Oncology, 2011
Bookmarks Related papers MentionsView impact
International Journal of Oncology, 2010
Bookmarks Related papers MentionsView impact
Uploads
Papers by Prof. Dr. Mine Ergüven