Papers by Richard O Phillips
Journal of Hepatology, Apr 1, 2015
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PLOS Neglected Tropical Diseases, Mar 3, 2021
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Clinical and Vaccine Immunology, 2009
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PLOS Neglected Tropical Diseases, Feb 21, 2013
<p>A. MS analysis of ASL from Mu infected human skin showing a molecule with m/z 765.5 whic... more <p>A. MS analysis of ASL from Mu infected human skin showing a molecule with m/z 765.5 which represents the sodium adduct of mycolactone A/B [M+Na<sup>+</sup>]. B. MS-MS analysis of this ion produced the core lactone ring of mycolactone with m/z 429.4 and the polyketide side chain of mycolactone A/B with m/z 359.2.</p
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Open Forum Infectious Diseases
BackgroundCoagulopathy is common in acute symptomatic Plasmodium falciparum malaria, and the degr... more BackgroundCoagulopathy is common in acute symptomatic Plasmodium falciparum malaria, and the degree of coagulation abnormality correlates with parasitemia and disease severity. Chronic asymptomatic malaria has been associated with increased morbidity. However, the role of coagulation activation in asymptomatic, semi-immune individuals remains unclear. This study investigates the potential effect of asymptomatic P falciparum infection on coagulation activation in semi-immune Ghanaian adults.MethodsBlood from asymptomatic Ghanaian adults with P falciparum blood stage infection detectable by polymerase chain reaction (PCR) or by both PCR and rapid diagnostic test and from noninfected individuals, was investigated. Markers of coagulation activation including global coagulation tests, D-dimer, antithrombin III, fibrinogen, and von Willebrand factor antigen were tested. Furthermore, blood count, inflammation markers, and liver and kidney function tests were assessed.ResultsAcquired coagul...
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Bulletin of The World Health Organization, Oct 1, 2005
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PLOS Neglected Tropical Diseases, 2020
Background There is a dearth of data on scabies from Ghana. In September 2019, local health autho... more Background There is a dearth of data on scabies from Ghana. In September 2019, local health authorities in the East Mamprusi district of northern Ghana received reports of scabies from many parts of the district. Due to on-going reports of more cases, an assessment team visited the communities to assess the effect of the earlier individual treatment on the outbreak. The assessment team furthermore aimed to contribute to the data on scabies burden in Ghana and to demonstrate the use of the International Alliance for the Control of Scabies (IACS) diagnostic tool in a field survey in a resource limited setting. Methodology/Principal findings This was a cross sectional study. Demographic information and medical history was collected on all participants using a REDCap questionnaire. A standardised skin examination of exposed regions of the body was performed on all participants. Scabies was diagnosed based on the criteria of the International Alliance for the Control of Scabies (IACS). P...
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SSRN Electronic Journal, 2019
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BackgroundBuruli ulcer (BU) is a disabling and stigmatising neglected tropical disease (NTD). Its... more BackgroundBuruli ulcer (BU) is a disabling and stigmatising neglected tropical disease (NTD). Its distribution and burden are unknown because of underdiagnosis and underreporting. It is caused by Mycobacterium ulcerans, an environmental pathogen whose environmental niche and transmission routes are not fully understood. Active BU case searches can limit morbidity by identifying cases and linking them to treatment, but these are mostly restricted to well-known endemic areas. A better understanding of environmental suitability for environmental reservoirs of M. ulcerans and BU disease would advance understanding of the disease’s ecology and burden, and could inform targeted surveillance.Methodology/Principal FindingsWe used previously compiled point-level datasets of BU and M. ulcerans occurrence, evidence for BU occurrence within national and sub-national areas, and diverse environmental datasets. We fitted relationships between BU and M. ulcerans occurrence and environmental predict...
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PLOS Neglected Tropical Diseases, 2019
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PLOS ONE, 2019
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The Lancet Global Health, 2019
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PLOS Neglected Tropical Diseases, 2019
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The Lancet. Global health, Apr 1, 2018
A dose of 30 mg/kg of azithromycin is recommended for treatment of yaws, a disease targeted for g... more A dose of 30 mg/kg of azithromycin is recommended for treatment of yaws, a disease targeted for global eradication. Treatment with 20 mg/kg of azithromycin is recommended for the elimination of trachoma as a public health problem. In some settings, these diseases are co-endemic. We aimed to determine the efficacy of 20 mg/kg of azithromycin compared with 30 mg/kg azithromycin for the treatment of active and latent yaws. We did a non-inferiority, open-label, randomised controlled trial in children aged 6-15 years who were recruited from schools in Ghana and schools and the community in Papua New Guinea. Participants were enrolled based on the presence of a clinical lesion that was consistent with infectious primary or secondary yaws and a positive rapid diagnostic test for treponemal and non-treponemal antibodies. Participants were randomly assigned (1:1) to receive either standard-dose (30 mg/kg) or low-dose (20 mg/kg) azithromycin by a computer-generated random number sequence. Hea...
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PLoS neglected tropical diseases, 2016
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a neglected tropical disease frequently l... more Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a neglected tropical disease frequently leading to permanent disabilities. The ulcers are treated with rifampicin and streptomycin, wound care and, if necessary surgical intervention. Professionals have exclusively shaped the research agenda concerning management and control, while patients' perspective on priorities and preferences have not explicitly been explored or addressed. To get insight into patient perception of the management and control of Buruli ulcer a mixed methods research design was applied with a questionnaire and focus group discussions among former BU patients. Data collection was obtained in collaboration with a local team of native speakers in Ghana. A questionnaire was completed by 60 former patients and four focus group discussions were conducted with eight participants per group. Former patients positively evaluated both the effectiveness of the treatment and the financial contribution received for t...
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The American journal of tropical medicine and hygiene, Jan 12, 2016
Buruli ulcer (BU) is one of the 17 neglected tropical diseases for which the World Health Organiz... more Buruli ulcer (BU) is one of the 17 neglected tropical diseases for which the World Health Organization has adopted resolutions to improve treatment. BU was previously described as a relatively painless condition; however, recent research has indicated that some patients experience substantial pain. The objective of this study was to explore patients' experiences of pain and their expectations for its treatment. Semistructured interviews were conducted in a BU-endemic region of Ghana. Interviews were held with former BU patients (N = 20) and community controls (N = 19). Former patients were asked about BU-related pain and their expectations for its treatment. The interviews were conducted in October 2014, and were audiotaped, translated and transcribed into English, and then qualitatively analyzed. Of the 20 former BU patients interviewed, 19 (95%) reported experiencing pain, with patients reporting pain as a consequence of the ulcer and wound management. Some participants expres...
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Chronic Wound Care Management and Research, 2016
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<p><a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001756#p... more <p><a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001756#pntd-0001756-g001" target="_blank">Figure 1</a> describes enrolment criteria for clinically suspected BUD patients presenting at Agogo Presbyterian Hospital (<i>n</i> = 14) and Tepa Governmental Hospital (<i>n</i> = 10), Ghana, respectively. None of the eligible study participants was excluded.</p
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International Journal of Mycobacteriology, 2016
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BMC nephrology, 2015
HIV infection is associated with increased risk of renal dysfunction, including tubular dysfuncti... more HIV infection is associated with increased risk of renal dysfunction, including tubular dysfunction (TD) related to antiretroviral therapy (ART). Tenofovir disoproxil fumarate (TDF) is becoming available for ART in sub-Saharan Africa, although data on its long-term safety there is limited. We aimed to study the prevalence of HIV-associated renal dysfunction in Ghana and explore associations between proteinuria or TD and potential risk factors, including TDF use. A single-centre cross-sectional observational study of patients taking ART was undertaken. Creatinine clearance (CrCl) was calculated and proteinuria detected with dipsticks. Spot urinary albumin and protein:creatinine ratios (uACR/uPCR) were measured and further evidence of TD (defined as having two or more characteristic features) sought. Logistic regression analysis identified factors associated with proteinuria or TD. In 330 patients, of whom 101 were taking TDF (median 20 months), the prevalence of CrCl < 60ml/min/1....
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Papers by Richard O Phillips