Chelsea Bahney, PhD
Associate Professor
Orthopaedic Surgery
School of Medicine

To accomplish this “Developmental Engineering” approach our laboratory utilizes a cross-disciplinary tools combining biologically modified synthetic polymers, stem cell biology, and murine models of orthopaedic injuries. The long-term goal of our research is to solve problems that will have a direct and significant impact on human health.

Current Projects:

(1) Tissue engineering strategies to promote endochondral bone regeneration (2) Transdifferentiation of cartilage to bone during fracture repair and osteoarthritis (3) The role of the nerve in fracture repair (4) Polytraumatic Injuries: How brain trauma influences fracture healing (5) Impedance sensors to monitor fracture healing

• Evaluating the Morphology of Unique Superficial Fissured Cartilage Lesions at the Femoral Head-Neck Junction in Patients with Femoroacetabular Impingement Syndrome.
  Orthopaedic journal of sports medicine 2024 Yamaura K, Nishimura H, Ruzbarsky JJ, Kuhns BD, Mullen MT, Duke VR, O'Hara KM, Brown JM, Comfort SM, Hambright WS, Bahney CS, Huard J, Philippon MJ
• Mineral coated microparticles doped with fluoride and complexed with mRNA prolong transfection in fracture healing.
  Frontiers in bioengineering and biotechnology 2024 Nelson AL, Fontana G, Chubb L, Choe J, Williams K, Regan D, Huard J, Murphy W, Ehrhart N, Bahney C
• Compliant substrates mitigate the senescence associated phenotype of stress induced mesenchymal stromal cells.
  Journal of biomedical materials research. Part A 2023 Gresham RCH, Filler AC, Fok SW, Czachor M, Schmier N, Pearson C, Bahney C, Leach JK
• Engineered Decellularized Tendon Matrix Putty Preserves Native Tendon Bioactivity to Promote Cell Proliferation and Enthesis Repair.
  Journal of Tissue Engineering and Regenerative Medicine 2023 Anna-Laura Nelson, Kelsey M. O’Hara, Philip C. Nolte, Naomasa Fukase, Yoichi Murata, Anna-Katharina Nolte, Johnny Huard, David L. Bernholt, Peter J. Millett, Chelsea S. Bahney
• A Systemic and Local Comparison of Senescence in an Acute Anterior Cruciate Ligament Injury-A Pilot Case Series.
  Life (Basel, Switzerland) 2023 Waltz RA, Whitney KE, Duke VR, Kloser H, Huard C, Provencher MT, Philippon MJ, Bahney C, Godin JA, Huard J
• Therapeutic potential of senolytic agent quercetin in osteoarthritis: A systematic review and meta-analysis of preclinical studies.
  Ageing research reviews 2023 Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C, Philippon MJ, Huard J
• Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair.
  Frontiers in bioengineering and biotechnology 2023 Rivera KO, Cuylear DL, Duke VR, O'Hara KM, Zhong JX, Elghazali NA, Finbloom JA, Kharbikar BN, Kryger AN, Miclau T, Marcucio RS, Bahney CS, Desai TA
• The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24-/- Progeria Mouse Model.
  Journal of osteoporosis 2023 Hambright WS, Mu X, Gao X, Guo P, Kawakami Y, Mitchell J, Mullen M, Nelson AL, Bahney C, Nishimura H, Hellwinkel J, Eck A, Huard J
• Sustained-release losartan from peptide nanofibers promotes chondrogenesis.
  Frontiers in bioengineering and biotechnology 2023 Yamaura K, Sather NA, Metlushko A, Nishimura H, Pavlovic RZ, Hambright S, Ravuri SK, Philippon MJ, Stupp SI, Bahney CS, Huard J
• Altered early immune response after fracture and traumatic brain injury.
  Frontiers in immunology 2023 Haffner-Luntzer M, Weber B, Morioka K, Lackner I, Fischer V, Bahney C, Ignatius A, Kalbitz M, Marcucio R, Miclau T
• Macromolecular crowding and decellularization method increase the growth factor binding potential of cell-secreted extracellular matrices.
  Frontiers in bioengineering and biotechnology 2023 Fok SW, Gresham RCH, Ryan W, Osipov B, Bahney C, Leach JK
• The effects of losartan or angiotensin II receptor antagonists on cartilage: a systematic review.
  Osteoarthritis and cartilage 2022 Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C, Philippon MJ, Huard J
• Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel.
  Science advances 2022 Li J, Sudiwala S, Berthoin L, Mohabbat S, Gaylord EA, Sinada H, Cruz Pacheco N, Chang JC, Jeon O, Lombaert IMA, May AJ, Alsberg E, Bahney CS, Knox SM
• Cellular expansion of MSCs: Shifting the regenerative potential.
  Aging cell 2022 Miclau K, Hambright WS, Huard J, Stoddart MJ, Bahney CS
• Mechanical strain drives exosome production, function, and miRNA cargo in C2C12 muscle progenitor cells.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2022 Mullen M, Williams K, LaRocca T, Duke V, Hambright WS, Ravuri SK, Bahney CS, Ehrhart N, Huard J
• A Shifting Paradigm: Transformation of Cartilage to Bone during Bone Repair.
  Journal of dental research 2022 Marcucio RS, Miclau T, Bahney CS
• The effects of fisetin on bone and cartilage: A systematic review.
  Pharmacological research 2022 Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C, Philippon MJ, Huard J
• Therapeutic approaches to activate the canonical Wnt pathway for bone regeneration.
  Journal of tissue engineering and regenerative medicine 2022 Nelson AL, Fontana G, Miclau E, Rongstad M, Murphy W, Huard J, Ehrhart N, Bahney C
• Wireless Measurements Using Electrical Impedance Spectroscopy to Monitor Fracture Healing.
  Sensors (Basel, Switzerland) 2022 Fukase N, Duke VR, Lin MC, Stake IK, Huard M, Huard J, Marmor MT, Maharbiz MM, Ehrhart NP, Bahney CS, Herfat ST
• Poster 217: Local and Systemic Comparison of Senescent Profiles in Acute Knee Injury.
  Orthopaedic Journal of Sports Medicine 2022 Kaitlyn Whitney, Heidi Kloser, Charles Huard, Chelsea Bahney, Matthew Provencher, Jonathan Godin, Johnny Huard, Robert Waltz
• Bone turnover markers as surrogates of fracture healing after intramedullary fixation of tibia and femur fractures.
  Bone & joint research 2022 Stewart CC, O'Hara NN, Bzovsky S, Bahney CS, Sprague S, Slobogean GP, Vita-Shock Investigators
• Collagen X Longitudinal Fracture Biomarker Suggests Staged Fixation in Tibial Plateau Fractures Delays Rate of Endochondral Repair.
  Journal of orthopaedic trauma 2022 Working ZM, Peterson D, Lawson M, O'Hara K, Coghlan R, Provencher MT, Friess DM, Johnstone B, Miclau T, Bahney CS
• The intersection of fracture healing and infection: Orthopaedics research society workshop 2021.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2022 Hellwinkel JE, Working ZM, Certain L, García AJ, Wenke JC, Bahney CS
• A timeseries analysis of the fracture callus extracellular matrix proteome during bone fracture healing.
  Journal of life sciences (Westlake Village, Calif.) 2021 Erickson CB, Hill R, Pascablo D, Kazakia G, Hansen K, Bahney C
• Revisiting Arnoczky: Measuring the Microvascular Anatomy of Young Adult Menisci.
  Arthroscopy The Journal of Arthroscopic and Related Surgery 2021 Matthew D. Crawford, Justin Hellwinkel, Zachary Aman, Ramesses Akamefula, Thomas Singleton, Chelsea Bahney, Robert LaPrade
• Growth factor delivery using extracellular matrix-mimicking substrates for musculoskeletal tissue engineering and repair.
  Bioactive materials 2020 Gresham RCH, Bahney CS, Leach JK
• Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion.
  Scientific reports 2020 Rivera KO, Russo F, Boileau RM, Tomlinson RE, Miclau T, Marcucio RS, Desai TA, Bahney CS
• Chondrocyte-to-osteoblast transformation in mandibular fracture repair.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Wong SA, Hu DP, Slocum J, Lam C, Nguyen M, Miclau T, Marcucio RS, Bahney CS
• Microvascular Anatomy and Intrinsic Gene Expression of Menisci From Young Adults.
  The American journal of sports medicine 2020 Crawford MD, Hellwinkel JE, Aman Z, Akamefula R, Singleton JT, Bahney C, LaPrade RF
• The Life of a Fracture: Biologic Progression, Healing Gone Awry, and Evaluation of Union.
  JBJS reviews 2020 Hellwinkel JE, Miclau T, Provencher MT, Bahney CS, Working ZM
• A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Working ZM, Morris ER, Chang JC, Coghlan RF, Johnstone B, Miclau T, Horton WA, Bahney CS
• The platelet-rich plasma and mesenchymal stem cell milieu: A review of therapeutic effects on bone healing.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Liebig BE, Kisiday JD, Bahney CS, Ehrhart NP, Goodrich LR
• Exosome Production and Regenerative Potential is Influenced by Mechanical Stimulus and Cell Origin.
  The FASEB Journal 2020 Michael Mullen, Chelsea Bahney, Sudheer Ravuri, Johnny Huard, Nicole Ehrhart
• Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.
  Scientific reports 2019 Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS
• Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Haffner-Luntzer M, Foertsch S, Fischer V, Prystaz K, Tschaffon M, Mödinger Y, Bahney CS, Marcucio RS, Miclau T, Ignatius A, Reber SO
• Challenging the paradigms in the classroom: the fate of chondrocytes.
  The FASEB Journal 2019 Chelsea S. Bahney
• Smart bone plates can monitor fracture healing.
  Scientific reports 2019 Lin MC, Hu D, Marmor M, Herfat ST, Bahney CS, Maharbiz MM
• Cellular biology of fracture healing.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2018 Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, Miclau T, Marcucio RS, Hankenson KD
• A degradation fragment of type X collagen is a real-time marker for bone growth velocity.
  2018 Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA
• Origin of Reparative Stem Cells in Fracture Healing.
  Current osteoporosis reports 2018 Bragdon BC, Bahney CS
• Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering.
  Frontiers in bioengineering and biotechnology 2018 Wong SA, Rivera KO, Miclau T, Alsberg E, Marcucio RS, Bahney CS
• A degradation fragment of type X collagen is a real-time marker for bone growth velocity.
  Science translational medicine 2017 Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA
• Using impedance to track fracture healing rates in mice in vivo: A pilot study.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2017 Lin MC, Hu D, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM
• New opportunities for fracture healing detection: Impedance spectroscopy measurements correlate to tissue composition in fractures.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2017 Lin MC, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM
• Fortifying the Bone-Implant Interface Part 1: An In Vitro Evaluation of 3D-Printed and TPS Porous Surfaces.
  International journal of spine surgery 2017 MacBarb RF, Lindsey DP, Bahney CS, Woods SA, Wolfe ML, Yerby SA
• Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing?
  Frontiers in cell and developmental biology 2017 Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T
• Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes.
  Development (Cambridge, England) 2017 Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS
• Accelerating the pace of discovery in orthopaedic research: A vision toward team science.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016 Bahney CS, Bruder SP, Cain JD, Keyak JH, Killian ML, Shapiro IM, Jones LC
• Matrix Reloaded: Devitalized Cartilage as a Functional Extracellular Niche to Promote Osteogenesis and Angiogenesis.
  The FASEB Journal 2016 Jaselle M Perry, Donna M Poscablo, Brandon T Gaston, Diane P Hu, Theodore Miclau, Karen L Christman, Ralph S Marcucio, Chelsea S Bahney
• Trans differentiation of Chondrocytes to Osteoblasts during Endochondral Ossification in the Healing Mandible.
  The FASEB Journal 2016 Sarah Anne Wong, Diane Hu, Theodore Miclau, Chelsea Bahney, Ralph Marcucio
• Transdifferentiation of Chondrocytes to Osteoblasts during Bone Fracture Healing.
  The FASEB Journal 2016 Ralph Marcucio, Diane Hu, Frank Yang, Chelsea Bahney, Theodore Miclau
• Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes.
  Tissue engineering. Part A 2016 Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC
• Inflammation, Bone Healing, and Anti-Inflammatory Drugs: An Update.
  Journal of orthopaedic trauma 2015 Giannoudis PV, Hak D, Sanders D, Donohoe E, Tosounidis T, Bahney C
• Stem Cell Therapies in Orthopaedic Trauma.
  Journal of orthopaedic trauma 2015 Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T
• Tissue engineering strategies for promoting vascularized bone regeneration.
  Bone 2015 Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C
• The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells.
  Acta biomaterialia 2015 Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S
• Review Article
  The multifaceted role of the vasculature in endochondral fracture repair 2015 Bahney, CS; Hu, DP; Miclau, T; Marcucio, RS
• The multifaceted role of the vasculature in endochondral fracture repair.
  Frontiers in endocrinology 2015 Bahney CS, Hu DP, Miclau T, Marcucio RS
• Impedance spectroscopy to monitor fracture healing.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2015 Lin MC, Herfat ST, Bahney CS, Marmor M, Maharbiz MM
• Endochondral bone tissue engineering: using cartilage to drive vascularized bone regeneration (87.6).
  The FASEB Journal 2014 Chelsea Bahney, Amit Jha, Diane Hu, Aaron Taylor, Hayley Britz, Benedikt Hallgrimsson, Ted Miclau, Ralph Marcucio
• Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6).
  The FASEB Journal 2014 Chelsea Bahney, Aaron Taylor, Ali Sadat, Kathryn Tormos, Ted Miclau, Emin Maltepe, Ralph Marcucio
• Transdifferentiation of hypertrophic chondrocytes during endochondral bone repair by activation of pluripotent stem cell programs (216.1).
  The FASEB Journal 2014 Chelsea Bahney, Diane Hu, Federico Ferro, Aaron Taylor, Ted Miclau, Ralph Marcucio
• 9 Cartilage grafts for bone repair and regeneration.
  Bone Substitute Biomaterials 2014 C.S. Bahney, R.S. Marcucio
• Contributor contact details.
  Bone Substitute Biomaterials 2014 K.K. Mallick, S. Sprio, M. Sandri, M. Iafisco, A. Ruffini, S. Minardi, A. Tampieri, P. Bhattacharya, G.H. van Lenthe, E.B. Hunziker, T.J. Blokhuis, V. Guarino, M.G. Raucci, A. Ronca, V. Cirillo, L. …
• Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS
• Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects.
  Journal of Visualized Experiments 2012 Yan-yiu Yu, Chelsea Bahney, Diane Hu, Ralph S. Marcucio, Theodore Miclau, III
• Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects.
  Journal of visualized experiments : JoVE 2012 Yu YY, Bahney C, Hu D, Marcucio RS, Miclau T
• Tissue engineering bone by recapitulating developmental and repair programs offers improved biological outcomes.
  The FASEB Journal 2012 Chelsea Shields Bahney, Diane Hu, Theodore Miclau, Ralph Marcucio
• Therapeutic potential of stem cells in orthopedics.
  Indian journal of orthopaedics 2012 Bahney CS, Miclau T
• Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels.
  European cells & materials 2011 Bahney CS, Lujan TJ, Hsu CW, Bottlang M, West JL, Johnstone B
• A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Bahney CS, Hsu CW, Yoo JU, West JL, Johnstone B
• A novel bioreactor for the dynamic stimulation and mechanical evaluation of multiple tissue-engineered constructs.
  Tissue engineering. Part C, Methods 2010 Lujan TJ, Wirtz KM, Bahney CS, Madey SM, Johnstone B, Bottlang M
• Temporal exposure to chondrogenic factors modulates human mesenchymal stem cell chondrogenesis in hydrogels.
  Tissue engineering. Part A 2010 Buxton AN, Bahney CS, Yoo JU, Johnstone B