NICHD 2025 strategic planning

NICHD has now released an RFI on the 2025 Strategic Plan research priorities. The RFI is open for public comment until September 27, 2024.

1st Asian Xenopus Conference

November 24, 2024 (Sun) to November 26, 2024 (Tues).

Osaka University, Osaka, Japan.

Registration and Abstract submission date: October 12, 2024.

Registration Open

Conference Website

Non-coding cause of congenital heart defects

Variants in the transcription factor zinc finger of the cerebellum 3 (ZIC3) cause heterotaxy, a disorder characterized by severe congenital heart defects. Wells et al. identified an X-linked heterotaxy pedigree without a coding variant - a deep intronic variant (ZIC3 c.1224+3286A>G) predicted to alter RNA splicing.

CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes

CDCA7 recruits he SNF2 family ATPase HELLS to chromatin in Xenopus egg extracts but not vice versa. CDCA7 directly recognizes hemimethylated DNA. The CDCA7-HELLS nucleosome remodeling complex assists the maintenance of DNA methylation on chromatin by sensing hemimethylated CpG that is otherwise inaccessible to additional methylation.

Single-cell profiling of Xenopus mucociliary epithelium

Lee et al. profile the developing Xenopus mucociliary epithelium (MCE) from pluripotent to mature stages by single-cell transcriptomics.

In Memoriam: Dr. Joseph Gall, Father of Modern Cell Biology

Joseph Gall, called the founder of modern cell biology for his contributions to our understanding of chromosomes and the cellular nucleus, and a widely recognized champion for women in science, died September 12. He was 96.

Discovering Frog Development in Unprecedented Detail

Laznovsky et al. utilized micro-computed tomography (micro-CT), a noninvasive 3-dimensional (3D) imaging technique with micrometer-scale resolution, to explore the developmental dynamics and morphological changes in Xenopus laevis. Published in GigaScience.

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20th International Xenopus Conference

Save the date!

Portsmouth, UK

August 17-21, 2025

NICHD 2025 strategic planning

NICHD has now released an RFI on the 2025 Strategic Plan research priorities. The RFI is open for public comment until September 27, 2024.