Abstract
Vaccinia virus, effectively used for immunization against smallpox, now serves as a recombinant vector for the development of vaccines against other infectious agents and cancer. Recent advances have led to increased gene expression, enhanced immunogenicity, and greater safety. Both replicating and host-restricted non-replicating vectors are available.
MeSH terms
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Defective Viruses / genetics*
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Defective Viruses / immunology
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Defective Viruses / physiology
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Genetic Vectors*
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Genome, Viral
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Promoter Regions, Genetic
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Vaccines, Attenuated
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Vaccines, Synthetic*
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Vaccinia virus / genetics*
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Vaccinia virus / immunology
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Vaccinia virus / physiology
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Virus Replication*
Substances
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Vaccines, Attenuated
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Vaccines, Synthetic