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Immunization with Aβ3-10-KLH vaccine improves cognitive function and ameliorates mitochondrial dysfunction and reduces Alzheimer's disease-like pathology in Tg-APPswe/PSEN1dE9 mice

Brain Res Bull. 2021 Sep:174:31-40. doi: 10.1016/j.brainresbull.2021.05.019. Epub 2021 May 24.

Abstract

Alzheimer's disease is a common cause of dementia, for which no disease-modifying therapy is yet available. Aβ3-10-KLH, a vaccine for active immunization, has been shown to prevent pathological changes in young transgenic models of AD, but the effects of treatment with it and its effects on mitochondrial dysfunction remain unclear. We immunized 6-month-old Tg-APPswe/PSEN1dE9 mice with Aβ3-10-KLH to analyze whether it is capable of eliminating amyloid-β after its appearance. The vaccine effectively decreased amyloid-β deposits, improved cognitive function and ameliorated mitochondrial dysfunction. These results indicate the potential of Aβ3-10-KLH as a vaccine to treat AD.

Keywords: Alzheimer’s disease; Amyloid-β; Aβ3-10-KLH vaccine; Mitochondrial dysfunction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / prevention & control*
  • Alzheimer Disease / psychology
  • Alzheimer Vaccines / therapeutic use*
  • Amyloid beta-Protein Precursor / genetics*
  • Amyloid beta-Protein Precursor / immunology
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Cognition
  • Cognition Disorders / prevention & control*
  • Cognition Disorders / psychology*
  • Humans
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mitochondrial Diseases / metabolism
  • Mitochondrial Diseases / prevention & control*
  • Presenilin-1 / genetics*
  • Vaccines / therapeutic use*

Substances

  • APP protein, mouse
  • Abeta3-10-KLH vaccine
  • Alzheimer Vaccines
  • Amyloid beta-Protein Precursor
  • Presenilin-1
  • Vaccines
  • presenilin 1, mouse