Asparagine and Glutamine: Co-conspirators Fueling Metastasis

Cell Metab. 2018 May 1;27(5):947-949. doi: 10.1016/j.cmet.2018.04.012.

Authors

Ming Luo¹, Michael Brooks², Max S Wicha³

Affiliations

¹ University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mingluo@med.umich.edu.
² University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
³ University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mwicha@med.umich.edu.

PMID: 29719230
DOI: 10.1016/j.cmet.2018.04.012

Abstract

Cancer cells frequently hijack normal metabolic pathways to promote their growth and metastasis. Two recent papers by Knott et al. (2018) and Pavlova et al. (2018) demonstrate that asparagine and glutamine work in concert to drive tumor growth and metastasis through modulation of cell survival, growth, and EMT regulatory pathways.

Publication types

Comment

MeSH terms

Asparagine*
Biological Availability
Breast Neoplasms*
Glutamine
Humans
Metabolic Networks and Pathways

Substances

Glutamine
Asparagine

Grants and funding

R35 CA197585/CA/NCI NIH HHS/United States