Abstract
Nanocrystallization of organic molecular photosensitizers (PSs) by means of NMOF platforms has been demonstrated to be a promising approach to build up highly efficient PDT therapeutics. We report herein a new UiO-66 type of NMOF-based PS (UiO-66-TPP-SH), which is generated from UiO-66 NMOF and S-ethylthiol ester monosubstituted metal free porphyrin (TPP-SH) via a facile postsynthetic approach under mild conditions. The obtained NMOF (size less than 150 nm) with surface-decorated porphyrinic PS can not only retain MOF crystallinity, structural feature, and size, but also exhibit highly efficient singlet oxygen generation. Compared to the interior-located porphyrinic NMOF, UiO-66-TPP-SH shows significantly higher photodynamic activity and more efficient PDT tumor treatment.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Metal-Organic Frameworks / chemical synthesis
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Metal-Organic Frameworks / chemistry
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Metal-Organic Frameworks / pharmacology*
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Molecular Structure
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Nanostructures / chemistry*
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Particle Size
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Photochemotherapy*
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology*
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Porphyrins / chemistry
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Porphyrins / pharmacology*
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Structure-Activity Relationship
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Surface Properties
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Tumor Cells, Cultured
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Zirconium / chemistry*
Substances
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Antineoplastic Agents
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Metal-Organic Frameworks
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Photosensitizing Agents
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Porphyrins
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Zirconium