Abstract
A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Factor Xa Inhibitors / chemical synthesis*
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Factor Xa Inhibitors / pharmacology
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Morpholines / chemical synthesis*
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Morpholines / pharmacology
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Proton Magnetic Resonance Spectroscopy
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Rivaroxaban
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
Substances
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Factor Xa Inhibitors
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Morpholines
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Thiophenes
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Rivaroxaban