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Magnetoporation and magnetolysis of cancer cells via carbon nanotubes induced by rotating magnetic fields

Nano Lett. 2012 Oct 10;12(10):5117-21. doi: 10.1021/nl301928z. Epub 2012 Sep 10.

Abstract

Weak magnetic fields (40 and 75 mT) were used either to enhance cell membrane poration (magnetoporation) or to ablate cultured human tumor cells (magnetolysis) by polymer-coated multiwalled carbon nanotubes, which form rotating bundles on exposure to magnetic fields. Findings of this study have potential clinical applications including enhanced tumor cell poration for targeted cancer chemotherapy and mechanical ablation of tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy
  • Cell Membrane Permeability
  • Female
  • Humans
  • MCF-7 Cells
  • Magnetic Field Therapy / methods*
  • Microscopy, Atomic Force
  • Microscopy, Electron, Scanning
  • Nanotechnology
  • Nanotubes, Carbon* / ultrastructure
  • Rotation

Substances

  • Nanotubes, Carbon