Abstract
A new oxazole (1) was obtained from Chinese insect medicine Aspongopus chinensis, along with three known N-acetyldopamine derivatives (2-4). Their structures were determined on the basis of NMR and ESI-MS analyses. The possible biosynthetic pathways of the isolated compounds are discussed. Cytotoxicities of those compounds against 10 selected cancer cells were measured in vitro.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Products / chemistry*
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Biological Products / pharmacology
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Biosynthetic Pathways
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Cell Line, Tumor
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Dopamine / analogs & derivatives*
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Dopamine / biosynthesis
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Dopamine / isolation & purification
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Dopamine / pharmacology
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Hemiptera / chemistry*
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Humans
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Molecular Structure
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Neoplasms / drug therapy
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Oxazoles / isolation & purification*
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Oxazoles / metabolism*
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Oxazoles / pharmacology
Substances
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Biological Products
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Oxazoles
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N-acetyldopamine
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Dopamine