Abstract
Polihexanide is a broad-spectrum antiseptic with excellent tolerance and a low-risk profile. The physicochemical action on the bacterial envelope prevents or impedes the development of resistant bacterial strains. Thus, polihexanide is particularly suitable and useful in the struggle against multidrug-resistant bacteria. The ecological database is still incomplete. There is some evidence that biodegradation requires adsorption to inert surfaces and that only a small number of bacterial species are capable of utilizing polihexanide.
Copyright © 2010 S. Karger AG, Basel.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents, Local* / adverse effects
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Anti-Infective Agents, Local* / chemistry
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Anti-Infective Agents, Local* / pharmacology
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Bacteria / drug effects
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Biguanides* / adverse effects
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Biguanides* / chemistry
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Biguanides* / pharmacology
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Biofilms*
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Disinfectants / pharmacology
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Drug Delivery Systems
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Drug Resistance, Microbial
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Drug Resistance, Multiple
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Humans
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Pseudomonas aeruginosa* / drug effects
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Skin
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Staphylococcus aureus* / drug effects
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Wound Infection / drug therapy
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Wound Infection / prevention & control
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents, Local
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Biguanides
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Disinfectants
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polihexanide