Cadmium (Cd) is a highly toxic heavy metal that induces genotoxic damage in the body. Besides, Cd induces oxidative damage in various tissues by altering antioxidant defence enzymes system. In this study, we investigated the protective role of royal jelly (RJ) on Cd-induced genotoxicity and oxidative stress in mice. For this aim, the micronucleus (MN) test in erythrocytes and exfoliated cells of buccal mucosa and the chromosome aberration (CA) test in bone marrow cells were applied. In addition, the levels of reduced glutathione (GSH) and malondialdehyde (MDA) were evaluated in the liver and kidneys. Thirty-six animals were divided into six groups: the control group received distilled water alone, whereas mice in the treatment groups received RJ alone (100 and 250 mg/kg of body weight), Cd alone (2 mg/kg of body weight), and RJ+Cd. Cd toxicity resulted in a significant (P < .05) increase in CAs, abnormal metaphase number, and MN formation. Cd also caused a decrease in mitotic index. Oral administration of RJ at two doses (100 and 250 mg/kg of body weight) showed significant (P < .05) suppression of mutagenic effects of Cd. Moreover, Cd-induced oxidative damage caused a significant decrease in GSH level and a significant increase in MDA level in the liver and kidneys. Treatment with two doses of RJ caused a significant recovery in antioxidant status of GSH and a significant inhibition of MDA production. It could be concluded that RJ has a protective role against Cd-induced genotoxicity and oxidative stress in mice, due to its antioxidant effects.