Abstract
Hypertension is a disorder controlled by multiple genes and inflammation and vascular remodelling of arteries have been implicated in pathogenesis of this disease. Green tea polyphenols (GrTPs) are rich in antioxidants and are known to inhibit inflammatory responses. A significant time-dependent increase in mRNA expression of both IL-6 and MMP-9 were observed in THP-1 macrophages when cultured in normocholesterolaemic hypertensive sera (P<0.05).
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / pharmacology*
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Cells, Cultured
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Flavonoids / pharmacology*
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Gene Expression
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Humans
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Hypertension / blood*
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Interleukin-6 / genetics*
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Macrophages / physiology*
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Matrix Metalloproteinase 9 / genetics*
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Phenols / pharmacology*
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Plant Extracts / pharmacology
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Polyphenols
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RNA, Messenger / analysis
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Reverse Transcriptase Polymerase Chain Reaction
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Tea*
Substances
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Antioxidants
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Flavonoids
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Interleukin-6
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Phenols
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Plant Extracts
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Polyphenols
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RNA, Messenger
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Tea
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Matrix Metalloproteinase 9