Abstract
We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
MeSH terms
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Amino Acid Substitution
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Antifungal Agents / pharmacology*
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Base Sequence
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Cloning, Molecular
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Colony Count, Microbial
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Drug Resistance, Fungal / genetics*
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Ergosterol / biosynthesis
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Naphthalenes / pharmacology*
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Sequence Analysis, DNA
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Squalene Monooxygenase / chemistry
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Squalene Monooxygenase / metabolism
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Terbinafine
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Trichophyton / drug effects*
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Trichophyton / isolation & purification
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Trichophyton / metabolism*
Substances
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Antifungal Agents
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Naphthalenes
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Squalene Monooxygenase
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Terbinafine
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Ergosterol