Abstract
The contribution of long polar fimbriae to intestinal colonization by Escherichia coli O157:H7 was evaluated in sheep, conventional pigs, and gnotobiotic piglets. E. coli O157:H7 strains with lpfA1 and lpfA2 mutated were recovered in significantly lower numbers and caused fewer attachment and effacement lesions than the parent strain.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Escherichia coli Infections / microbiology
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Escherichia coli Infections / pathology
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Escherichia coli O157 / classification*
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Escherichia coli O157 / genetics
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Escherichia coli O157 / pathogenicity*
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Escherichia coli O157 / physiology
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism
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Feces / microbiology
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Fimbriae, Bacterial / chemistry*
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Fimbriae, Bacterial / genetics
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Fimbriae, Bacterial / physiology*
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Food Microbiology
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Intestines / microbiology*
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Intestines / pathology
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Mutation / genetics
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Sheep / microbiology*
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Swine / microbiology*
Substances
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Escherichia coli Proteins