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The prostate as a reservoir for HIV-1

AIDS. 2004 Jul 23;18(11):1600-2. doi: 10.1097/01.aids.0000131364.60081.01.

Abstract

As the prostate can harbor bacterial and fungal pathogens, it was investigated as a reservoir for HIV. Nine men chronically infected with HIV participated in a crossover trial in which weekly semen samples were collected with and without previous prostate massage (PM). Six of the nine participants had undetectable seminal plasma(SP) HIV RNA in all samples without previous PM, but had detectable SP HIV RNA (> 25 copies/ml) in one to three samples collected after PM.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cross-Over Studies
  • Disease Reservoirs*
  • HIV Infections / transmission
  • HIV Infections / virology*
  • HIV-1*
  • Humans
  • Male
  • Physical Examination
  • Prostate / virology*
  • Prostatic Diseases / virology*
  • RNA, Viral / analysis
  • Semen / chemistry
  • Semen / virology

Substances

  • RNA, Viral