Abstract
Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3T3 Cells
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Animals
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Antigens, Ly / chemistry
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Antigens, Ly / genetics
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Antigens, Ly / immunology*
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Antigens, Ly / metabolism
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Cell Line
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Coculture Techniques
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Disease Susceptibility
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Evolution, Molecular
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Herpesviridae Infections / immunology*
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Histocompatibility Antigens Class I / immunology
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Hybridomas
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Immunity, Innate
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Interferon-gamma / biosynthesis
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Killer Cells, Natural / immunology*
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Lectins, C-Type
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Ligands
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Lymphocyte Activation
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / immunology*
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Membrane Glycoproteins / metabolism
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Muromegalovirus / genetics
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Muromegalovirus / immunology*
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Muromegalovirus / metabolism
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NK Cell Lectin-Like Receptor Subfamily A
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Protein Binding
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Receptors, Immunologic / chemistry
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Receptors, Immunologic / genetics
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Receptors, Immunologic / immunology*
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Receptors, Immunologic / metabolism
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Receptors, NK Cell Lectin-Like
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Recombinant Fusion Proteins / metabolism
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Transfection
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Viral Proteins / chemistry
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Viral Proteins / genetics
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Viral Proteins / immunology*
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Viral Proteins / metabolism
Substances
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Antigens, Ly
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Histocompatibility Antigens Class I
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Klra8 protein, mouse
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Lectins, C-Type
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Ligands
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Ly49I antigen
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Membrane Glycoproteins
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NK Cell Lectin-Like Receptor Subfamily A
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Receptors, Immunologic
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Receptors, NK Cell Lectin-Like
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Recombinant Fusion Proteins
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Viral Proteins
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Interferon-gamma