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Bayesian semiparametric models for survival data with a cure fraction

Biometrics. 2001 Jun;57(2):383-8. doi: 10.1111/j.0006-341x.2001.00383.x.

Abstract

We propose methods for Bayesian inference for a new class of semiparametric survival models with a cure fraction. Specifically, we propose a semiparametric cure rate model with a smoothing parameter that controls the degree of parametricity in the right tail of the survival distribution. We show that such a parameter is crucial for these kinds of models and can have an impact on the posterior estimates. Several novel properties of the proposed model are derived. In addition, we propose a class of improper noninformative priors based on this model and examine the properties of the implied posterior. Also, a class of informative priors based on historical data is proposed and its theoretical properties are investigated. A case study involving a melanoma clinical trial is discussed in detail to demonstrate the proposed methodology.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bayes Theorem*
  • Humans
  • Likelihood Functions
  • Melanoma / mortality
  • Melanoma / secondary
  • Melanoma / therapy
  • Models, Statistical*
  • Neoplasm Metastasis
  • Neoplasms / mortality
  • Neoplasms / therapy
  • Predictive Value of Tests
  • Survival Analysis*
  • Treatment Failure
  • Treatment Outcome