Objective To identify the most commonly presenting conditions in primary care globally, and
to compare common reasons for visits (RFVs) as reported by clinicians and patients, as well …

Background Skeletal muscle cramps are common and often occur in association with
pregnancy, advanced age, exercise or motor neuron disorders (such as amyotrophic lateral …

Background Eight out of 10 major antihypertensive trials in older adults attempted to achieve
a target systolic blood pressure (BP) less than 160 mmHg. Collectively these trials …

Concerns about the veracity of psychological research have been growing. Many findings in
psychological science are based on studies with insufficient statistical power and …

In response to DNA damage, the p53 tumor suppressor can elicit either apoptosis or cell-
cycle arrest and repair, but how this critical decision is made in specific cell types remains …

Adoptive therapy using chimeric antigen receptor-modified T cells (CAR-T cells) is effective
in hematologic but not epithelial malignancies, which cause the greatest mortality. In breast …

Existing (binary) understandings of gender affirm some types of gendered accounts as
“authentic,” while others are discredited or obscured. As a consequence, many transgender …

The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or
apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein …

The domestic dog is becoming an increasingly valuable model species in medical genetics,
showing particular promise to advance our understanding of cancer and orthopaedic …

Free fatty acids (FFA) induce hepatocyte lipoapoptosis by a c-Jun N-terminal kinase (JNK)-
dependent mechanism. However, the cellular processes by which JNK engages the core …