Array technologies have made it straightforward to monitor simultaneously the expression
pattern of thousands of genes. The challenge now is to interpret such massive data sets. The …

The characterization of cancer genomes has provided insight into somatically altered genes
across tumors, transformed our understanding of cancer biology, and enabled tailoring of …

Summary The Cancer Genome Atlas Network recently cataloged recurrent genomic
abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression …

DNA microarrays can be used to identify gene expression changes characteristic of human
disease. This is challenging, however, when relevant differences are subtle at the level of …

Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group
of tumours about which little is known biologically, and whose diagnosis, on the basis of …

Summary The Molecular Signatures Database (MSigDB) is one of the most widely used and
comprehensive databases of gene sets for performing gene set enrichment analysis. Since …

Although genomewide RNA expression analysis has become a routine tool in biomedical
research, extracting biological insight from such information remains a major challenge …

Although cancer classification has improved over the past 30 years, there has been no
general approach for identifying new cancer classes (class discovery) or for assigning …

The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are
aggressive and respond poorly to standard therapies. Although the identification of specific …

Prostate tumors are among the most heterogeneous of cancers, both histologically and
clinically. Microarray expression analysis was used to determine whether global biological …