During the past few years studies from several laboratories have utilized gene disruption
approaches to define the function of members of the Stat family of transcription factors. The …

Many cytokines mediate their biological effects through interaction with a distinct family of
receptors termed the cytokine receptor superfamily. Although members of this family lack …

A variety of cytokines, lymphokines and growth factors functionsby interacting with receptors
that are members of the cytokine receptor superfamily. These receptors share extracellular …

A variety of cytokines mediate the activation of Janus protein tyrosine kinases (Jaks). The
Jaks then phosphorylate cellular substrates, including members of the signal transducers …

Erythropoietin(EPO) regulates the proliferation and differentiation of erythroid cells through
interaction with its receptor (EPOR). Although EPOR is a member of the cytokine receptor …

A variety of cytokines activate receptor-associated members of the Janus family of protein
tyrosine kinases (Jaks). To assess the role of Jak2, we have derived Jak2-deficient mice …

SIGNAL transducers and activators of transcription (STATs) are activated by tyrosine
phosphorylation in response to cytokines and mediate many of their functional responses1 …

SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine-
and T cell receptor–independent manner. SOCS1 deletion causes perinatal lethality with …

SIGNAL transducers and activators of transcription (Stats) are activated by tyrosine
phosphorylation in response to cytokines, and are thought to mediate many of their …

Abstract Interleukin 3 (IL 3) was initially defined as a factor in conditioned media from
concanavalin A-stimulated lymphocytes (Con A CM) that induces the enzyme 20-alpha …