User profiles for "author:D McDonnell"

Donald P. McDonnell - Verified email at duke.edu - Cited by 41871
Duncan McDonnell - Verified email at griffith.edu.au - Cited by 5583

Connections and regulation of the human estrogen receptor

DP McDonnell, JD Norris - Science, 2002 - science.org
Estrogen regulates a plethora of functionally dissimilar processes in a broad range of
tissues. Recent progress in the study of the molecular mechanism of action of estrogen (s) …

The molecular pharmacology of SERMs

DP McDonnell - Trends in Endocrinology & Metabolism, 1999 - cell.com
Estrogen-containing medicines have been used successfully for the past 50 years for the
treatment of conditions associated with menopause. Although initially considered a …

[HTML][HTML] Coregulators in nuclear estrogen receptor action

JM Hall, DP McDonnell - Molecular interventions, 2005 - triggered.edina.clockss.org
Estrogens are key regulators of growth, differentiation, and the physiological functions of a
wide range of target tissues, including the male and female reproductive tracts, breast, and …

The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to …

JM Hall, DP McDonnell - Endocrinology, 1999 - academic.oup.com
The human estrogen receptor α (ERα) and the recently identified ERβ share a high degree
of amino acid homology; however, there are significant differences in regions of these …

Molecular cloning of complementary DNA encoding the avian receptor for vitamin D

DP McDonnell, DJ Mangelsdorf, JW Pike, MR Haussler… - Science, 1987 - science.org
Vitamin D3 receptors are intracellular proteins that mediate the nuclear action of the active
metabolite 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3]. Two receptor-specific monoclonal …

The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding

PH Giangrande, EA Kimbrel, DP Edwards… - … and cellular biology, 2000 - Am Soc Microbiol
The human progesterone receptor (PR) exists as two functionally distinct isoforms, hPRA
and hPRB. hPRB functions as a transcriptional activator in most cell and promoter contexts …

Human progesterone receptor A form is a cell-and promoter-specific repressor of human progesterone receptor B function.

E Vegeto, MM Shahbaz, DX Wen… - Molecular …, 1993 - academic.oup.com
Two distinct isoforms of the human progesterone receptor (hPR-A and hPR-B) have been
identified previously. They differ only in that hPR-B contains an additional 164 amino acids …

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

DP McDonnell, DL Clemm, T Hermann… - Molecular …, 1995 - academic.oup.com
We have developed a series of in vitro models with which to evaluate the biological activity
of estrogen receptor (ER) agonists and antagonists. Using a protease digestion assay we …

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

AR Baker, DP McDonnell, M Hughes… - Proceedings of the …, 1988 - National Acad Sciences
Complementary DNA clones encoding the human vitamin D receptor have been isolated
from human intestine and T47D cell cDNA libraries. The nucleotide sequence of the 4605 …

Introduction: The sceptre and the spectre

D Albertazzi, D McDonnell - Twenty-first century populism: The spectre of …, 2008 - Springer
Ghiţa Ionescu and Ernest Gellner (1969: 1) began their classic edited collection on populism
by paraphrasing Marx and Engel's famous opening line:'A Spectre is haunting the world …