The majority of estrogen receptor (ER)-positive breast cancers are treated with endocrine
therapy. While this is effective, acquired resistance to therapies targeted against ER is a …

In breast cancer, inactivation of the RB tumor suppressor gene is believed to occur via
multiple mechanisms to facilitate tumorigenesis. However, the prognostic and predictive …

Background Cell lines are used in experimental investigation of cancer but their capacity to
represent tumor cells has yet to be quantified. The aim of the study was to identify significant …

Recently, we proposed a new mechanism for understanding the Warburg effect in cancer
metabolism. In this new paradigm, cancer-associated fibroblasts undergo aerobic glycolysis …

Previously, we showed that high-energy metabolites (lactate and ketones)“fuel” tumor
growth and experimental metastasis in an in vivo xenograft model, most likely by driving …

We have recently proposed a new mechanism for explaining energy transfer in cancer
metabolism. In this scenario, cancer cells behave as metabolic parasites, by extracting …

Retinoblastoma (RB; encoded by RB1) is a tumor suppressor that is frequently disrupted in
tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of …

Exosomes, secreted microvesicles transporting microRNAs (miRNAs), mRNAs, and proteins
through bodily fluids, facilitate intercellular communication and elicit immune responses …

The mechanisms underlying adaptive resistance of melanoma to targeted therapies remain
unclear. By combining ChIP sequencing with microarray-based gene profiling, we …

The roles of the chemokine CCL5 and its receptor CCR5 in breast cancer progression
remain unclear. Here, we conducted microarray analysis on 2,254 human breast cancer …