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Antiretroviral Drug Resistance Among Children and Youth in the United States With Perinatal HIV

Clin Infect Dis. 2016 Jul 1;63(1):133-137. doi: 10.1093/cid/ciw213. Epub 2016 Apr 7.

Abstract

Among 234 US youths with perinatal human immunodeficiency virus, 75% had antiretroviral resistance, substantially higher than that of the reference laboratory overall (36%-44%). Resistance to newer antiretrovirals and to all antiretrovirals in a class was uncommon. The only factor independently associated with future resistance was a higher peak viral load.

Keywords: adolescents; antiviral resistance; children; human immunodeficiency virus; perinatal infection.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Anti-HIV Agents / pharmacology*
  • Anti-HIV Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Drug Resistance, Viral*
  • Female
  • HIV Infections* / drug therapy
  • HIV Infections* / epidemiology
  • HIV Infections* / transmission
  • HIV Infections* / virology
  • HIV-1 / drug effects*
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical*
  • Male
  • Prevalence
  • Prospective Studies
  • United States / epidemiology

Substances

  • Anti-HIV Agents