Maryland Bionetworking Summit: October 1st
Please join us on Tuesday, October 1st from 6-8pm for our bioscience-focused networking event series designed to highlight the area’s unique life science ecosystem and to promote interactions between its diverse stakeholders. Sponsored and organized by the University of Maryland, Baltimore County (UMBC), the Institute for Bioscience and Biotechnology Research...
IBBR Researchers Collaborate with the FDA to evaluate wNMR for Biomanufacturing Automation
Dr. Bruce Yu, IBBR Fellow and MPower Professor, of the University of Maryland, School of Pharmacy, along with Drs. Marc Taraban, Katharine Briggs, and Pallavi Guha-Biswas have been collaborating with the FDA through the Maryland-Center of Excellence in Regulatory Science and Innovation (M-CERSI) on a regulatory science challenge. The FDA...
Dr. David Weber Recognized as Distinguished University Professor
Dr. David Weber, Co-Director of the Institute for Bioscience and Biotechnology Research (IBBR), Director of the Center for Biomolecular Therapeutics (CBT) and Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine, has been recognized with the designation of Distinguished University Professor. A...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Wednesday, September 25, 2024 - 11:00am
Pin-Kuang Lai
Stevens Institute of Technology
Monday, September 30, 2024 - 11:00am
NIST Group Meeting; Navleen Kaur
Wednesday, October 2, 2024 - 11:00am
Recent Publications
Electrobiofabrication of antibody sensor interfaces within a 3D printed device yield rapid and robust electrochemical measurements of titer and glycan structure.
We report the integration of 3D printing, electrobiofabrication, and protein engineering to create a device that enables near real-time analysis of monoclonal antibody (mAb) titer and quality. 3D...
Anisotropic coarse-grain Monte Carlo simulations of lysozyme, lactoferrin, and NISTmAb by precomputing atomistic models.
We develop a multiscale coarse-grain model of the NIST Monoclonal Antibody Reference Material 8671 (NISTmAb) to enable systematic computational investigations of high-concentration physical...
Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on "Structural insights into the regulation of RyR1 by S100A1".
S100A1, a calcium-binding protein, plays a crucial role in regulating Ca2+ signaling pathways in skeletal and cardiac myocytes via interactions with the ryanodine receptor (RyR) to affect Ca2+...
Solution NMR backbone resonance assignment of the full-length resistance-related calcium-binding protein Sorcin.
Sorcin is a penta-EF hand calcium-binding protein that confers multidrug resistance in cancer cells. It regulates cellular Ca2+ homeostasis by interacting with calcium channels such as Ryanodine...
Structural and Functional Insights into the Delivery Systems of Bacillus and Clostridial Binary Toxins.
Pathogenic Bacillus and clostridial (i.e., Clostridium and Clostridioides) bacteria express a diverse repertoire of effector proteins to promote disease. This includes production of binary toxins,...