- Review Article
- Pulmonology
- Evidence-based management guidelines for noncystic fibrosis bronchiectasis in children and adolescents
- Eun Lee, Kyunghoon Kim, You Hoon Jeon, In Suk Sol, Jong Deok Kim, Taek Ki Min, Yoon Ha Hwang, Hyun-Ju Cho, Dong In Suh, Hwan Soo Kim, Yoon Hee Kim, Sung-Il Woo, Yong Ju Lee, Sungsu Jung, Hyeon-Jong Yang, Gwang Cheon Jang
- Clin Exp Pediatr. 2024;67(9):418-426. Published online January 23, 2024
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· We suggest offering long-term macrolides to children with noncystic fibrosis bronchiectasis with frequent exacerbations (conditional recommendation, moderate quality of evidence).
· We do not recommend the routine use of mucolytic agents, inhaled corticosteroids, or nonsteroidal anti-inflammatory drugs to prevent exacerbation of bronchiectasis in children (inconclusive, very low quality of evidence).
· We recommend the use of nebulized hypertonic saline to prevent exacerbations and improve the lung function of children with noncystic fibrosis bronchiectasis (weak recommendation, moderate quality of evidence).
- Infection
- Incidence, causative organisms, and risk factors of bloodstream infections in pediatric liver transplant patients: a systematic review
- Mohamad Shieb, Rand Hasanain, Zara Arshad, Faisal A. Nawaz, Rahul Kashyap, Eric J. Stern
- Clin Exp Pediatr. 2024;67(9):427-434. Published online April 5, 2024
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The overall incidence of bloodstream infections was 23.5%. Gram-negative organisms occur at a much higher rate in pediatric liver transplant recipients then that the general pediatric population. However, when comparing pediatric and adult liver transplant recipients Gram-positive organisms occur with a much higher rate in the pediatric population highlighting the importance of early and broad spectrum antimicrobial coverage when bloodstream infections are suspected.
- Developmental and Behavioral Medicine
- Comprehensive evaluation of the child with global developmental delays or intellectual disability
- Abdullah Nasser Aldosari, T. Saeed Aldosari
- Clin Exp Pediatr. 2024;67(9):435-446. Published online May 29, 2024
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· A detailed history and comprehensive physical examination remain the cornerstones for establishing a diagnosis of global developmental delay/intellectual disability (GDD/ID).
· Comprehensive surveillance and screening programs play a significant role in the early detection of GDD.
· Whole-exome sequencing is highly recommended as first- or second-line testing for individuals with idiopathic GDD/ID.
· Early intervention by a well-versed multidisciplinary team can significantly improve the outcomes and prognosis of GDD/ID.
- Allergy
- Comparison and review of international guidelines for treating asthma in children
- Eui Jeong Roh
- Clin Exp Pediatr. 2024;67(9):447-455. Published online August 20, 2024
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Asthma is the most common chronic disease among children. Although asthma in children may spontaneously improve, it continues into adulthood in many cases. Therefore, appropriate disease management and medication are essential. Consistent and objective guidelines are needed to manage pediatric asthma and related adverse reactions.
- Editorial
- Neurology
- Impact of COVID-19 pandemic on clinical features of benign convulsions with mild gastroenteritis
- Jon Soo Kim
- Clin Exp Pediatr. 2024;67(9):456-458. Published online March 25, 2024
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· The frequency of benign convulsions with mild gastroenteritis (CwG) was not significantly influenced by the pandemic.
· The coronavirus disease 2019 pandemic has further diversified the etiologic enteric viral pathogens of CwG.
- Original Article
- Developmental and Behavioral Medicine
- Neonatal risk factors associated with autism spectrum disorders: an umbrella review
- Amir Mohammad Salehi, Erfan Ayubi, Salman Khazaei, Ensiyeh Jenabi, Saeid Bashirian, Zohreh Salimi
- Clin Exp Pediatr. 2024;67(9):459-464. Published online July 19, 2024
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Question: What are the neonatal risk factors for autism spectrum disorder (ASD)?
Findings: Significant effect sizes were observed for congenital heart disease (odds ratio [OR], 1.35), macrosomia (OR, 1.11), low birth weight (OR, 1.63), very low birth weight (OR, 2.25), small for gestational age (OR, 1.17), jaundice (OR, 1.74), male sex (OR, 1.47), and Apgar score (OR, 1.40).
Meaning: These factors were identified as risk factors for ASD.
- Genetics and Metabolism
- Interleukin (IL)-1B and IL-1 receptor antagonist gene polymorphisms in children with primary immune thrombocytopenia
- Seham Mohamed Ragab, Wafaa Moustafa Abo ElFotoh, Mahmoud Ahmed El-Hawy, Eman Abdelfatah Badr, Saara Khairat Ali Mostafa, Mai El-Sayad Abd El-Hamid
- Clin Exp Pediatr. 2024;67(9):465-473. Published online July 24, 2024
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· Polymorphisms in interleukin (IL)-1B and IL-1 receptor (IL-1R) antagonists may significantly affect the pathogenesis of immune thrombocytopenia (ITP).
· IL-1B and IL-1R antagonist gene polymorphisms are correlated with severity and susceptibility to primary ITP in children.
- Letter to the Editor
- Gastroenterology
- Pediatric abdominal ultrasound training program for pediatricians
- Soon Chul Kim
- Clin Exp Pediatr. 2024;67(9):474-476. Published online August 20, 2024
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