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Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Octylcaffeate Induced Apoptosis in Human Leukemia U937 Cells
Mayuko Ujibe, Syu-ichi Kanno, Yu Osanai, Kimiko Koiwai,  Department of Pharmacology and Pharmacy, Tohoku Pharmaceutical University">Takaharu Ohtake, Katsuhiko Kimura, Kohji Uwai, Mitsuhiro Takeshita, Masaaki Ishikawa
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Keywords: octylcaffeate, apoptosis, caspase, U937
JOURNAL FREE ACCESS

2005 Volume 28 Issue 12 Pages 2338-2341

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Abstract

We found that octylcaffeate, a semisynthetic caffeic acid derivative, strongly inhibited the growth of human histiolytic lymphoma U937 cells in a dose- and time-dependent manner via apoptosis. Octylcaffeate induced the fragmentation of DNA into multiples of 180 bp (an apoptotic DNA ladder) and condensation of chromatin, and increased the percentage of hypodiploid cells detected with a flow cytometer. DNA fragmentation induced by octylcaffeate was inhibited by pretreatment with Z-DEVD-FMK and Z-Asp-CH2D-CB, an inhibitor of caspase, clearly showing that the mode of cell death is apoptotic. These findings suggest that the cytotoxicity of octylcaffeate involves the induction of apoptosis.

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© 2005 The Pharmaceutical Society of Japan
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